TY - JOUR
T1 - Discovering the nucleus in a world of biomaterials
AU - Vermeulen, Steven
AU - Balmayor, Elizabeth Rosado
N1 - Funding Information:
S.V. thanks the Gravitation Program of the Netherlands Organization for Scientific Research (NWO) (project 'Materials-Driven Regeneration'; grant no. 024.003.013 ). E.R.B. thanks for the support of NIH , grant R01 AR074395 from NIAMS. This work was supported by the Open Access Publishing Agreement \u201CProjekt DEAL\u201D between German Universities and Elsevier.
Publisher Copyright:
© 2024
PY - 2024/6/1
Y1 - 2024/6/1
N2 - The nucleus serves as the central hub for cellular activity, driving cell identity and behavior. Despite its crucial role, understanding how biomaterials influence the nucleus remains an underexplored area of research. In our opinion, this is an overlooked opportunity, particularly in regenerative medicine — a field where cellular control is not just beneficial, but essential. As such, we emphasize the need to recognize nuclear characteristics as a key metric for evaluating material functionality. In this leading opinion article, we discuss how state-of-the-art technologies can help reveal biomaterial-driven nuclear alterations, offering crucial insights that will advance the field of regenerative medicine.
AB - The nucleus serves as the central hub for cellular activity, driving cell identity and behavior. Despite its crucial role, understanding how biomaterials influence the nucleus remains an underexplored area of research. In our opinion, this is an overlooked opportunity, particularly in regenerative medicine — a field where cellular control is not just beneficial, but essential. As such, we emphasize the need to recognize nuclear characteristics as a key metric for evaluating material functionality. In this leading opinion article, we discuss how state-of-the-art technologies can help reveal biomaterial-driven nuclear alterations, offering crucial insights that will advance the field of regenerative medicine.
KW - Advanced technologies
KW - Biomaterial-driven nuclear alterations
KW - Mechanobiology
KW - Surface topography
U2 - 10.1016/j.bbiosy.2024.100096
DO - 10.1016/j.bbiosy.2024.100096
M3 - Article
SN - 2666-5344
VL - 14
JO - Biomaterials and Biosystems
JF - Biomaterials and Biosystems
M1 - 100096
ER -