TY - JOUR
T1 - Direct comparison of clinical decision limits for cardiac troponin T and I
AU - Kimenai, Dorien M.
AU - Henry, Ronald M. A.
AU - van der Kallen, Carla J. H.
AU - Dagnelie, Pieter C.
AU - Schram, Miranda T.
AU - Stehouwer, Coen D. A.
AU - van Suijlen, Jeroen D. E.
AU - Niens, Marijke
AU - Bekers, Otto
AU - Sep, Simone J. S.
AU - Schaper, Nicolaas C.
AU - van Dieijen-Visser, Marja P.
AU - Meex, Steven J. R.
PY - 2016/4
Y1 - 2016/4
N2 - Objective The 99th percentile upper reference limit of high-sensitivity cardiac troponin (hs-cTn) from a healthy reference population is used for diagnosing acute myocardial infarction (AMI). Accepted current thresholds of hs-cTnT (Roche) and hs-cTnI (Abbott) are 14 and 26ng/L, respectively. Since thresholds for hs-cTnT and hs-cTnI were derived from different reference cohorts it is unclear whether they are biologically equivalent. We directly assessed sex-specific and age-specific 99th percentile upper reference limits of hs-cTnT and hs-cTnI in a single reference cohort, to investigate whether current divergent thresholds of hs-cTnT and hs-cTnI stem from intrinsic assay differences or reflect cohort variation. Methods A healthy reference population was derived from a population-based cohort (the Maastricht Study: n=3451; age: 40-75years). Individuals with diabetes mellitus, a history of cardiovascular disease, cardiac ischaemia on ECG, N-terminal pro-brain natriuretic peptide >125ng/L or estimated glomerular filtration rate
AB - Objective The 99th percentile upper reference limit of high-sensitivity cardiac troponin (hs-cTn) from a healthy reference population is used for diagnosing acute myocardial infarction (AMI). Accepted current thresholds of hs-cTnT (Roche) and hs-cTnI (Abbott) are 14 and 26ng/L, respectively. Since thresholds for hs-cTnT and hs-cTnI were derived from different reference cohorts it is unclear whether they are biologically equivalent. We directly assessed sex-specific and age-specific 99th percentile upper reference limits of hs-cTnT and hs-cTnI in a single reference cohort, to investigate whether current divergent thresholds of hs-cTnT and hs-cTnI stem from intrinsic assay differences or reflect cohort variation. Methods A healthy reference population was derived from a population-based cohort (the Maastricht Study: n=3451; age: 40-75years). Individuals with diabetes mellitus, a history of cardiovascular disease, cardiac ischaemia on ECG, N-terminal pro-brain natriuretic peptide >125ng/L or estimated glomerular filtration rate
U2 - 10.1136/heartjnl-2015-308917
DO - 10.1136/heartjnl-2015-308917
M3 - Article
C2 - 26794233
SN - 1355-6037
VL - 102
SP - 610
EP - 616
JO - Heart
JF - Heart
IS - 8
ER -