Diffusion-weighted MRI with ADC mapping for response prediction and assessment of oesophageal cancer: A systematic review

Sophie E. Vollenbrock*, Francine E. M. Voncken, Lambertus W. Bartels, Regina G. H. Beets-Tan, Annemarieke Bartels-Rutten

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Citations (Web of Science)

Abstract

Purpose: The aim was to perform a systematic review on the value of diffusion-weighted MRI (DW-MRI) with apparent diffusion coefficient (ADC) mapping in the prediction and assessment of response to chemo- and/or radiotherapy in oesophageal cancer.

Materials and methods: A systematic search was performed on Pubmed, Embase, Medline and Cochrane databases. Studies that evaluated the ADC for response evaluation before, during or after chemo- and/or radiotherapy were included. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was used to assess the quality of the included studies.

Results: Fourteen studies, comprising 516 patients, in which the response to treatment in oesophageal cancer was evaluated on ADC maps were included. Acquisition parameter settings for DW-MRI and ROI placement varied substantially. The reference standard was RECIST or endoscopic assessment in eight non-surgery studies and histopathology after surgery in six studies. A high pre-treatment ADC significantly correlated with good response in three out of 12 studies; conversely, one study reported a significantly higher pre-treatment ADC in poor responders. In five out of eight studies good responders showed a significantly larger relative increase in ADC two weeks after the onset of treatment (range 23-59%) than poor responders (range 1.5-17%). After chemo- and/or radiotherapy ADC results varied considerably, amongst others due to large variation in the interval between completion of therapy and DW-MRI.

Conclusion: DW-MRI for response evaluation to chemo- and/or radiotherapy in oesophageal cancer shows variable methods and results. A large relative ADC increase after two weeks of treatment seems most predictive for good response. (C) 2019 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)17-26
Number of pages10
JournalRadiotherapy and Oncology
Volume142
DOIs
Publication statusPublished - Jan 2020

Keywords

  • MRI
  • Oesophageal cancer
  • Apparent diffusion coefficient
  • Response
  • SQUAMOUS-CELL CARCINOMA
  • NEOADJUVANT CHEMORADIOTHERAPY
  • F-18-FDG PET
  • PREOPERATIVE CHEMORADIOTHERAPY
  • DIAGNOSTIC PERFORMANCE
  • TUMOR-REGRESSION
  • COEFFICIENT
  • ADENOCARCINOMA
  • EVALUATE
  • VALUES

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