Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model

Aurore Lyon; Lauren J. Dupuis; Theo Arts; Harry J. G. M. Crijns; Frits W. Prinzen; Tammo Delhaas; Jordi Heijman; Joost Lumens

doi:10.1152/ajpheart.00275.2020

Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model

Aurore Lyon^*, Lauren J. Dupuis, Theo Arts, Harry J. G. M. Crijns, Frits W. Prinzen, Tammo Delhaas, Jordi Heijman, Joost Lumens

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	H519-H530
Number of pages	12
Journal	American Journal of Physiology-heart and Circulatory Physiology
Volume	319
Issue number	3
DOIs	https://doi.org/10.1152/ajpheart.00275.2020
Publication status	Published - Sep 2020

Keywords

calcium
cardiac electromechanical coupling
computer modeling
exercise
sarcomere
INTRACELLULAR CALCIUM
CARDIAC-MUSCLE
SARCOMERE-LENGTH
HUMAN MYOCARDIUM
CONTRACTION
TENSION
MECHANISMS
DYSFUNCTION
RELAXATION
TRANSIENTS

Access to Document

10.1152/ajpheart.00275.2020

Cite this

Lyon, A., Dupuis, L. J., Arts, T., Crijns, H. J. G. M., Prinzen, F. W., Delhaas, T., Heijman, J., & Lumens, J. (2020). Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model. American Journal of Physiology-heart and Circulatory Physiology, 319(3), H519-H530. https://doi.org/10.1152/ajpheart.00275.2020

Lyon, Aurore ; Dupuis, Lauren J. ; Arts, Theo ; Crijns, Harry J. G. M. ; Prinzen, Frits W. ; Delhaas, Tammo ; Heijman, Jordi ; Lumens, Joost. / Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model. In: American Journal of Physiology-heart and Circulatory Physiology. 2020 ; Vol. 319, No. 3. pp. H519-H530.

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title = "Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model",

keywords = "calcium, cardiac electromechanical coupling, computer modeling, exercise, sarcomere, INTRACELLULAR CALCIUM, CARDIAC-MUSCLE, SARCOMERE-LENGTH, HUMAN MYOCARDIUM, CONTRACTION, TENSION, MECHANISMS, DYSFUNCTION, RELAXATION, TRANSIENTS",

author = "Aurore Lyon and Dupuis, {Lauren J.} and Theo Arts and Crijns, {Harry J. G. M.} and Prinzen, {Frits W.} and Tammo Delhaas and Jordi Heijman and Joost Lumens",

year = "2020",

month = sep,

doi = "10.1152/ajpheart.00275.2020",

language = "English",

volume = "319",

pages = "H519--H530",

journal = "American Journal of Physiology-heart and Circulatory Physiology",

issn = "0363-6135",

publisher = "American Physiological Society",

number = "3",

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Lyon, A , Dupuis, LJ, Arts, T, Crijns, HJGM , Prinzen, FW , Delhaas, T , Heijman, J & Lumens, J 2020, 'Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model', American Journal of Physiology-heart and Circulatory Physiology, vol. 319, no. 3, pp. H519-H530. https://doi.org/10.1152/ajpheart.00275.2020

Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model. / Lyon, Aurore ; Dupuis, Lauren J.; Arts, Theo; Crijns, Harry J. G. M.; Prinzen, Frits W.; Delhaas, Tammo ; Heijman, Jordi ; Lumens, Joost.

In: American Journal of Physiology-heart and Circulatory Physiology, Vol. 319, No. 3, 09.2020, p. H519-H530.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Differentiating the effects of beta-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model

AU - Lyon, Aurore

AU - Dupuis, Lauren J.

AU - Arts, Theo

AU - Crijns, Harry J. G. M.

AU - Prinzen, Frits W.

AU - Delhaas, Tammo

AU - Heijman, Jordi

AU - Lumens, Joost

PY - 2020/9

Y1 - 2020/9

KW - calcium

KW - cardiac electromechanical coupling

KW - computer modeling

KW - exercise

KW - sarcomere

KW - INTRACELLULAR CALCIUM

KW - CARDIAC-MUSCLE

KW - SARCOMERE-LENGTH

KW - HUMAN MYOCARDIUM

KW - CONTRACTION

KW - TENSION

KW - MECHANISMS

KW - DYSFUNCTION

KW - RELAXATION

KW - TRANSIENTS

U2 - 10.1152/ajpheart.00275.2020

DO - 10.1152/ajpheart.00275.2020

M3 - Article

VL - 319

SP - H519-H530

JO - American Journal of Physiology-heart and Circulatory Physiology

JF - American Journal of Physiology-heart and Circulatory Physiology

SN - 0363-6135

IS - 3

ER -