TY - JOUR
T1 - Differential Time Course of Microstructural White Matter in Patients With Psychotic Disorder and Individuals at Risk
T2 - A 3-Year Follow-up Study
AU - Domen, Patrick
AU - Peeters, Sanne
AU - Michielse, Stijn
AU - Gronenschild, Ed
AU - Viechtbauer, Wolfgang
AU - Roebroeck, Alard
AU - Os, Jim van
AU - Marcelis, Machteld
AU - Genetic Risk and Outcome of Psychosis (GROUP) Investigators
N1 - © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.
PY - 2017/1
Y1 - 2017/1
N2 - BACKGROUND: Although widespread reduced white matter (WM) integrity is a consistent finding in cross-sectional diffusion tensor imaging (DTI) studies of schizophrenia, little is known about the course of these alterations. This study examined to what degree microstructural WM alterations display differential trajectories over time as a function of level of psychosis liability.METHODS: Two DTI scans with a 3-year time interval were acquired from 159 participants (55 patients with a psychotic disorder, 55 nonpsychotic siblings and 49 healthy controls) and processed with tract-based spatial statistics. The mean fractional anisotropy (FA) change over time was calculated. Main effects of group, as well as group × region interactions in the model of FA change were examined with multilevel (mixed-effects) models.RESULTS: Siblings revealed a significant mean FA decrease over time compared to controls (B = -0.004, P = .04), resulting in a significant sibling-control difference at follow-up (B = -0.007, P = .03). Patients did not show a significant change over time, but their mean FA was lower than controls both at baseline and at follow-up. A significant group × region interaction (χ(2) = 105.4, P = .01) revealed group differences in FA change in the right cingulum, left posterior thalamic radiation, right retrolenticular part of the internal capsule, and the right posterior corona radiata.CONCLUSION: Whole brain mean FA remained stable over a 3-year period in patients with psychotic disorder and declined over time in nonaffected siblings, so that at follow-up both groups had lower FA with respect to controls. The results suggest that liability for psychosis may involve a process of WM alterations.
AB - BACKGROUND: Although widespread reduced white matter (WM) integrity is a consistent finding in cross-sectional diffusion tensor imaging (DTI) studies of schizophrenia, little is known about the course of these alterations. This study examined to what degree microstructural WM alterations display differential trajectories over time as a function of level of psychosis liability.METHODS: Two DTI scans with a 3-year time interval were acquired from 159 participants (55 patients with a psychotic disorder, 55 nonpsychotic siblings and 49 healthy controls) and processed with tract-based spatial statistics. The mean fractional anisotropy (FA) change over time was calculated. Main effects of group, as well as group × region interactions in the model of FA change were examined with multilevel (mixed-effects) models.RESULTS: Siblings revealed a significant mean FA decrease over time compared to controls (B = -0.004, P = .04), resulting in a significant sibling-control difference at follow-up (B = -0.007, P = .03). Patients did not show a significant change over time, but their mean FA was lower than controls both at baseline and at follow-up. A significant group × region interaction (χ(2) = 105.4, P = .01) revealed group differences in FA change in the right cingulum, left posterior thalamic radiation, right retrolenticular part of the internal capsule, and the right posterior corona radiata.CONCLUSION: Whole brain mean FA remained stable over a 3-year period in patients with psychotic disorder and declined over time in nonaffected siblings, so that at follow-up both groups had lower FA with respect to controls. The results suggest that liability for psychosis may involve a process of WM alterations.
KW - psychotic disorder
KW - diffusion tensor imaging
KW - disease progression
KW - siblings
KW - DIFFUSION TENSOR TRACTOGRAPHY
KW - NEGATIVE-SYNDROME-SCALE
KW - 1ST EPISODE PSYCHOSIS
KW - LIFE-SPAN
KW - DISCONNECTION SYNDROME
KW - SPATIAL STATISTICS
KW - BIPOLAR DISORDER
KW - NAIVE PATIENTS
KW - SCHIZOPHRENIA
KW - INTEGRITY
U2 - 10.1093/schbul/sbw061
DO - 10.1093/schbul/sbw061
M3 - Article
C2 - 27190279
SN - 0586-7614
VL - 43
SP - 160
EP - 170
JO - Schizophrenia Bulletin
JF - Schizophrenia Bulletin
IS - 1
ER -