TY - JOUR
T1 - Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2
AU - Brants, J.R.
AU - Ayoubi, T.A.Y.
AU - Chada, K.
AU - van de Ven, W.J.
AU - Petit, M.M.
PY - 2004/1/1
Y1 - 2004/1/1
N2 - The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis. Little is known, however, about its downstream targets. We performed a search for genes of which expression is strongly altered during embryonic development in two HMGA2-deficient mouse strains, which display a pygmy-phenotype, as compared to wild-type mice. We found that the insulin-like growth factor II mRNA-binding protein 2 gene (IMP2), but not its family members IMP1 and IMP3, was robustly downregulated in mutant E12.5 embryos. Furthermore, we show that wild-type HMGA2 and its tumor-specific truncated form have opposite effects on IMP2 expression. Our results clearly indicate that HMGA2 differentially regulates expression of IMP family members during embryogenesis.
AB - The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis. Little is known, however, about its downstream targets. We performed a search for genes of which expression is strongly altered during embryonic development in two HMGA2-deficient mouse strains, which display a pygmy-phenotype, as compared to wild-type mice. We found that the insulin-like growth factor II mRNA-binding protein 2 gene (IMP2), but not its family members IMP1 and IMP3, was robustly downregulated in mutant E12.5 embryos. Furthermore, we show that wild-type HMGA2 and its tumor-specific truncated form have opposite effects on IMP2 expression. Our results clearly indicate that HMGA2 differentially regulates expression of IMP family members during embryogenesis.
U2 - 10.1016/j.febslet.2004.05.075
DO - 10.1016/j.febslet.2004.05.075
M3 - Article
C2 - 15225648
SN - 0014-5793
VL - 569
SP - 277
EP - 283
JO - Febs Letters
JF - Febs Letters
IS - 1-3
ER -