Differential Effects of the beta-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1-and SQT2-Mutant Channels

Ilona Bodi; Gerlind Franke; Naga Deepa Pantulu; Kezhong Wu; Stefanie Perez-Feliz; Christoph Bode; Manfred Zehender; Axel Zur Hausen; Michael Brunner; Katja E. Odening

doi:10.1111/jce.12178

Differential Effects of the beta-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1-and SQT2-Mutant Channels

Ilona Bodi
, Gerlind Franke
, Naga Deepa Pantulu
, Kezhong Wu
, Stefanie Perez-Feliz
, Christoph Bode
, Manfred Zehender
, Axel Zur Hausen
, Michael Brunner
, Katja E. Odening^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

-Blocker Effects on SQTS-Mutant K+ Channels BackgroundN588K-KCNH2 and V307L-KCNQ1 mutations lead to a gain-of-function of I-Kr and I-Ks thus causing short-QT syndromes (SQT1, SQT2). Combined pharmacotherapies using K+-channel-blockers and -blockers are ef

Original language	English
Pages (from-to)	1163-1171
Number of pages	9
Journal	Journal of Cardiovascular Electrophysiology
Volume	24
Issue number	10
DOIs	https://doi.org/10.1111/jce.12178
Publication status	Published - Oct 2013

Keywords

beta-adrenergic blocker
carvedilol
metoprolol
potassium current
short-QT syndrome

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10.1111/jce.12178

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@article{bde5f29442964a24aa0798929a457d17,

title = "Differential Effects of the beta-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1-and SQT2-Mutant Channels",

abstract = "-Blocker Effects on SQTS-Mutant K+ Channels BackgroundN588K-KCNH2 and V307L-KCNQ1 mutations lead to a gain-of-function of I-Kr and I-Ks thus causing short-QT syndromes (SQT1, SQT2). Combined pharmacotherapies using K+-channel-blockers and -blockers are ef",

keywords = "beta-adrenergic blocker, carvedilol, metoprolol, potassium current, short-QT syndrome",

author = "Ilona Bodi and Gerlind Franke and Pantulu, \{Naga Deepa\} and Kezhong Wu and Stefanie Perez-Feliz and Christoph Bode and Manfred Zehender and \{Zur Hausen\}, Axel and Michael Brunner and Odening, \{Katja E.\}",

year = "2013",

month = oct,

doi = "10.1111/jce.12178",

language = "English",

volume = "24",

pages = "1163--1171",

journal = "Journal of Cardiovascular Electrophysiology",

issn = "1045-3873",

publisher = "John Wiley \& Sons Inc.",

number = "10",

}

TY - JOUR

T1 - Differential Effects of the beta-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1-and SQT2-Mutant Channels

AU - Bodi, Ilona

AU - Franke, Gerlind

AU - Pantulu, Naga Deepa

AU - Wu, Kezhong

AU - Perez-Feliz, Stefanie

AU - Bode, Christoph

AU - Zehender, Manfred

AU - Zur Hausen, Axel

AU - Brunner, Michael

AU - Odening, Katja E.

PY - 2013/10

Y1 - 2013/10

N2 - -Blocker Effects on SQTS-Mutant K+ Channels BackgroundN588K-KCNH2 and V307L-KCNQ1 mutations lead to a gain-of-function of I-Kr and I-Ks thus causing short-QT syndromes (SQT1, SQT2). Combined pharmacotherapies using K+-channel-blockers and -blockers are ef

AB - -Blocker Effects on SQTS-Mutant K+ Channels BackgroundN588K-KCNH2 and V307L-KCNQ1 mutations lead to a gain-of-function of I-Kr and I-Ks thus causing short-QT syndromes (SQT1, SQT2). Combined pharmacotherapies using K+-channel-blockers and -blockers are ef

KW - beta-adrenergic blocker

KW - carvedilol

KW - metoprolol

KW - potassium current

KW - short-QT syndrome

U2 - 10.1111/jce.12178

DO - 10.1111/jce.12178

M3 - Article

C2 - 23718892

SN - 1045-3873

VL - 24

SP - 1163

EP - 1171

JO - Journal of Cardiovascular Electrophysiology

JF - Journal of Cardiovascular Electrophysiology

IS - 10

ER -

Differential Effects of the beta-Adrenoceptor Blockers Carvedilol and Metoprolol on SQT1-and SQT2-Mutant Channels

Abstract

Keywords

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