Differential effects of 5-HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and tryptophan challenge

C.R. Markus, R. De Raedt

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Previous data suggest that a polymorphism at the serotonin (5-HT) transporter gene (5-HTTLPR) may influence stress resilience and stress-related depression symptoms due to interactions between brain 5-HT dysfunction and stress exposure. Although attentional bias for emotional information has been reliably observed in depression, the interaction between 5-HT transporter-linked promoter region (5-HTTLPR), brain 5-HT vulnerability, and acute stress on affective information processing has not yet been investigated. This study examines the effects of tryptophan (TRP) augmentation (indicating 5-HT manipulation) on inhibition of negative emotional information under stress in mainly female S'/S'- vs L'/L'-allele carriers. A total of 15 female homozygotic short-allele 5-HTTLPR (S'/S' = S/S, S/L[sub]G[/sub], L[sub]G[/sub]/L[sub]G[/sub]) and 13 female homozygotic long-allele 5-HTTLPR (L'/L' = L[sub]A[/sub]/L[sub]A[/sub]) subjects were tested for mood and inhibition of emotional information in a double-blind, placebo-controlled design before and after stress exposure following TRP manipulation. Stress exposure significantly impaired inhibition of negative affective information only in S'/S' carriers, whereas L'/L' carriers even showed increased inhibition of negative information. The S'/S' allele 5-HTTLPR genotype increases cognitive-attentional bias for negative emotional information under acute stress. As this bias is an important component of depression, this may be a mediating mechanism making S'/S'-allele carriers more vulnerability for stress-induced depression symptoms. Moreover, current data suggest that L'/L'-allele genotypes are more resilient, even increasing cognitive emotional (inhibitory) control after stress. (PsycINFO Database Record (c) 2011 APA, all rights reserved) (journal abstract)
Original languageEnglish
Pages (from-to)819-826
Number of pages8
JournalNeuropsychopharmacology
Volume36
Issue number4
DOIs
Publication statusPublished - Mar 2011

Keywords

  • 5-HTTLPR
  • emotion processing
  • serotonin
  • stress
  • tryptophan
  • SEROTONIN TRANSPORTER GENE
  • PROMOTER POLYMORPHISM 5-HTTLPR
  • MAJOR DEPRESSION
  • 5-HYDROXYINDOLEACETIC ACID
  • UNIPOLAR DEPRESSION
  • LIFE EVENTS
  • ANTIDEPRESSANT ACTION
  • CEREBROSPINAL-FLUID
  • HEALTHY-VOLUNTEERS
  • BRAIN TRYPTOPHAN

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