TY - JOUR
T1 - Different prognostic models for different patient populations: validation of a new prognostic model for patients with oropharyngeal cancer in Western Europe
AU - Rietbergen, M. M.
AU - Witte, B. I.
AU - Velazquez, E. R.
AU - Snijders, P. J. F.
AU - Bloemena, E.
AU - Speel, E. J.
AU - Brakenhoff, R. H.
AU - Kremer, B.
AU - Lambin, P.
AU - Leemans, C. R.
PY - 2015/5/26
Y1 - 2015/5/26
N2 - Objective: The presence of human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) is a major determinant in prognostic risk modelling. Recently, a prognostic model was proposed in which HPV status, comorbidity and nodal stage were the most important prognostic factors to determine high-, intermediate-and low-risk survival groups. Here, we report on the validation of this model using an independent single-institutional cohort. Methods: A total number of 235 patients curatively treated for OPSCC in the period 2000-2011 at the MUMC (Maastricht University Medical Center, The Netherlands) were included. The presence of an oncogenic HPV infection was determined by p16 immunostaining, followed by a high-risk HPV DNA PCR on the p16-positive cases. The model variables included were HPV status, comorbidity and nodal stage. As a measure of model performance, the Harrell's Concordance index (Harrell's C-index) was used. Results: The 5-year overall survival (OS) estimates were 84.6%, 54.5% and 28.7% in the low-, intermediate-and high-risk group, respectively. The difference between the survival curves was highly significant (P
AB - Objective: The presence of human papillomavirus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) is a major determinant in prognostic risk modelling. Recently, a prognostic model was proposed in which HPV status, comorbidity and nodal stage were the most important prognostic factors to determine high-, intermediate-and low-risk survival groups. Here, we report on the validation of this model using an independent single-institutional cohort. Methods: A total number of 235 patients curatively treated for OPSCC in the period 2000-2011 at the MUMC (Maastricht University Medical Center, The Netherlands) were included. The presence of an oncogenic HPV infection was determined by p16 immunostaining, followed by a high-risk HPV DNA PCR on the p16-positive cases. The model variables included were HPV status, comorbidity and nodal stage. As a measure of model performance, the Harrell's Concordance index (Harrell's C-index) was used. Results: The 5-year overall survival (OS) estimates were 84.6%, 54.5% and 28.7% in the low-, intermediate-and high-risk group, respectively. The difference between the survival curves was highly significant (P
KW - human papillomavirus
KW - oropharyngeal cancer
KW - prognostic model validation
U2 - 10.1038/bjc.2015.139
DO - 10.1038/bjc.2015.139
M3 - Article
C2 - 25950384
SN - 0007-0920
VL - 112
SP - 1733
EP - 1736
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 11
ER -