TY - JOUR
T1 - Different and common brain signals of altered neurocognitive mechanisms for unfamiliar face processing in acquired and developmental prosopagnosia
AU - Olivares, Ela I.
AU - Urraca, Ana S.
AU - Lage-Castellanos, Agustin
AU - Iglesias, Jaime
N1 - Funding Information:
The present study was supported by “ Ministerio de Ciencia, Innovación y Universidades de España ” (Grant PGC2018-094937-B-100 ). We are grateful to Brad Duchaine, who facilitated us both the first contact with patient I.P. and a face detection test. We also thank Andrea Álvarez-San Millán for her help in data acquisition from the Control group and edition of both Fig. 1 and Supplementary Material 3_Stimuli .
Funding Information:
The present study was supported by ?Ministerio de Ciencia, Innovaci?n y Universidades de Espa?a? (Grant PGC2018-094937-B-100). We are grateful to Brad Duchaine, who facilitated us both the first contact with patient I.P. and a face detection test. We also thank Andrea ?lvarez-San Mill?n for her help in data acquisition from the Control group and edition of both Fig. 1 and Supplementary Material 3_Stimuli.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/1
Y1 - 2021/1
N2 - Neuropsychological studies have shown that prosopagnosic individuals perceive face structure in an atypical way. This might preclude the formation of appropriate face representations and, consequently, hamper effective recognition. The present ERP study, in combination with Bayesian source reconstruction, investigates how information related to both external (E) and internal (I) features was processed by E.C. and I.P., suffering from acquired and developmental prosopagnosia, respectively. They carried out a face-feature matching task with new faces. E.C. showed poor performance and remarkable lack of early face-sensitive P1, N170 and P2 responses on right (damaged) posterior cortex. Although she presented the expected mismatch effect to target faces in the E-I sequence, it was of shorter duration than in Controls, and involved left parietal, right frontocentral and dorsofrontal regions, suggestive of reduced neural circuitry to process face configurations. In turn, I.P. performed efficiently but with a remarkable bias to give “match” responses. His face-sensitive potentials P1–N170 were comparable to those from Controls, however, he showed no subsequent P2 response and a mismatch effect only in the I-E sequence, reflecting activation confined to those regions that sustain typically the initial stages of face processing. Relevantly, neither of the prosopagnosics exhibited conspicuous P3 responses to features acting as primes, indicating that diagnostic information for constructing face representations could not be sufficiently attended nor deeply encoded. Our findings suggest a different locus for altered neurocognitive mechanisms in the face network in participants with different types of prosopagnosia, but common indicators of a deficient allocation of attentional resources for further recognition.
AB - Neuropsychological studies have shown that prosopagnosic individuals perceive face structure in an atypical way. This might preclude the formation of appropriate face representations and, consequently, hamper effective recognition. The present ERP study, in combination with Bayesian source reconstruction, investigates how information related to both external (E) and internal (I) features was processed by E.C. and I.P., suffering from acquired and developmental prosopagnosia, respectively. They carried out a face-feature matching task with new faces. E.C. showed poor performance and remarkable lack of early face-sensitive P1, N170 and P2 responses on right (damaged) posterior cortex. Although she presented the expected mismatch effect to target faces in the E-I sequence, it was of shorter duration than in Controls, and involved left parietal, right frontocentral and dorsofrontal regions, suggestive of reduced neural circuitry to process face configurations. In turn, I.P. performed efficiently but with a remarkable bias to give “match” responses. His face-sensitive potentials P1–N170 were comparable to those from Controls, however, he showed no subsequent P2 response and a mismatch effect only in the I-E sequence, reflecting activation confined to those regions that sustain typically the initial stages of face processing. Relevantly, neither of the prosopagnosics exhibited conspicuous P3 responses to features acting as primes, indicating that diagnostic information for constructing face representations could not be sufficiently attended nor deeply encoded. Our findings suggest a different locus for altered neurocognitive mechanisms in the face network in participants with different types of prosopagnosia, but common indicators of a deficient allocation of attentional resources for further recognition.
KW - Acquired prosopagnosia
KW - Developmental prosopagnosia
KW - ERPs
KW - Face processing
KW - Unfamiliar faces
KW - EVENT-RELATED POTENTIALS
KW - SOURCE RECONSTRUCTION
KW - ELECTROMAGNETIC TOMOGRAPHY
KW - CONGENITAL PROSOPAGNOSIA
KW - EXTERNAL FEATURES
KW - INTERNAL FEATURES
KW - WORKING-MEMORY
KW - FAMILIAR FACES
KW - ANATOMIC BASIS
KW - ERP EVIDENCE
U2 - 10.1016/j.cortex.2020.10.017
DO - 10.1016/j.cortex.2020.10.017
M3 - Article
C2 - 33271437
SN - 0010-9452
VL - 134
SP - 92
EP - 113
JO - Cortex
JF - Cortex
ER -