TY - JOUR
T1 - Differences of Clinical Characteristics and Drug Prescriptions between Men and Women with COPD in China
AU - Zeng, Y.Q.
AU - Spruit, M.A.
AU - Deng, Q.C.
AU - Franssen, F.M.E.
AU - Chen, P.
N1 - Funding Information:
This work was supported by the National Key Clinical Specialty Construction Projects, the National Natural Science Foundation of China (NSFC; Grant 81770046), NSFC (Grant 81970044) and Xiangya Mingyi grant (2013).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Background: Sex differences in symptoms exist in patients with COPD. Our aim is to measure the differences between men and women with COPD, focusing on risk factors, symptoms, quality of life and drug prescriptions. Methods: In this cross-sectional observational study, patients with COPD were collected in China; demographic characteristics, smoking history, occupational exposure, biomass exposure, lung function, dyspnea, quality of life, and prescriptions for inhaled medications were collected. The nearest neighbor algorithm was used to match female and male patients (ratio 2:1) on age, body mass index, and lung function. Results: Compared with 1462 men, the 731 women generally had lower educational levels and were married less (both p < 0.001). A total of 576 (90.0%) women did not smoke cigarettes. More men were exposed to occupational dust (539 (36.9%) vs. 84 (11.5%), p = 0.013), while more women were exposed to biomass smoke (330 (45.1%) vs. 392 (26.8%), p = 0.004). Except for phlegm and chest tightness, women had more complaints than men for cough, breathlessness, activities, confidence, sleep and energy (p < 0.05). In addition, more women were prescribed triple therapy than men (236 (36.3%) vs. 388 (31.0%), p = 0.020). Conclusions: There are obvious discrepancies in the quality of life and use of inhaled medications between male and female patients with COPD.
AB - Background: Sex differences in symptoms exist in patients with COPD. Our aim is to measure the differences between men and women with COPD, focusing on risk factors, symptoms, quality of life and drug prescriptions. Methods: In this cross-sectional observational study, patients with COPD were collected in China; demographic characteristics, smoking history, occupational exposure, biomass exposure, lung function, dyspnea, quality of life, and prescriptions for inhaled medications were collected. The nearest neighbor algorithm was used to match female and male patients (ratio 2:1) on age, body mass index, and lung function. Results: Compared with 1462 men, the 731 women generally had lower educational levels and were married less (both p < 0.001). A total of 576 (90.0%) women did not smoke cigarettes. More men were exposed to occupational dust (539 (36.9%) vs. 84 (11.5%), p = 0.013), while more women were exposed to biomass smoke (330 (45.1%) vs. 392 (26.8%), p = 0.004). Except for phlegm and chest tightness, women had more complaints than men for cough, breathlessness, activities, confidence, sleep and energy (p < 0.05). In addition, more women were prescribed triple therapy than men (236 (36.3%) vs. 388 (31.0%), p = 0.020). Conclusions: There are obvious discrepancies in the quality of life and use of inhaled medications between male and female patients with COPD.
KW - COPD
KW - sex difference
KW - symptom
KW - prescription
KW - OBSTRUCTIVE PULMONARY-DISEASE
KW - SEX-RELATED DIFFERENCES
KW - GENDER
KW - RISK
KW - LUNG
KW - EXPOSURE
KW - BIOMASS
KW - EXACERBATIONS
KW - INEQUALITY
KW - MANAGEMENT
U2 - 10.3390/toxics11020102
DO - 10.3390/toxics11020102
M3 - Article
C2 - 36850977
SN - 2305-6304
VL - 11
JO - Toxics
JF - Toxics
IS - 2
M1 - 102
ER -