TY - JOUR
T1 - Differences in Virus Prevalence and Load in the Hearts of Patients with Idiopathic Dilated Cardiomyopathy with and without Immune-Mediated Inflammatory Diseases
AU - Dennert, Robert
AU - van Paassen, Pieter
AU - Wolffs, Petra
AU - Bruggeman, Catrien
AU - Velthuis, Sebastiaan
AU - Felix, Susanne
AU - van Suylen, Robert-Jan
AU - Crijns, Harry J.
AU - Tervaert, Jan Willem Cohen
AU - Heymans, Stephane
PY - 2012/8
Y1 - 2012/8
N2 - Infections with cardiotrophic viruses and immune-mediated responses against the heart have been suggested to play a dominant role in the pathogenesis of idiopathic dilated cardiomyopathy (DCM). Furthermore, immune-mediated inflammatory diseases (IMIDs) may result in DCM. It has not previously been assessed whether DCM patients with and without an IMID have different prevalences and quantities of cardiotrophic viruses in the heart. Therefore, we compared the profiles of cardiotrophic viruses in heart tissue of DCM patients with and without an IMID. Serum and myocardial tissue samples were obtained from 159 consecutive patients with DCM and 20 controls. Patients were subdivided into three groups, the first two based on the presence (n = 34) or absence (n = 125) of an IMID and the third being a control group. The parvovirus B19 virus genome was detected in equal quantities in the non-IMID DCM patients (100/125) and the control group (15/20) but in lower quantities in the IMID patients (21/34, P = 0.02). Both the non-IMID and IMID DCM patients demonstrated increased myocardial inflammation compared to controls: 12.5 +/- 1.8 and 14.0 +/- 3.2 CD45-positive inflammatory cells, respectively, versus 5.1 +/- 0.7 for the controls (P
AB - Infections with cardiotrophic viruses and immune-mediated responses against the heart have been suggested to play a dominant role in the pathogenesis of idiopathic dilated cardiomyopathy (DCM). Furthermore, immune-mediated inflammatory diseases (IMIDs) may result in DCM. It has not previously been assessed whether DCM patients with and without an IMID have different prevalences and quantities of cardiotrophic viruses in the heart. Therefore, we compared the profiles of cardiotrophic viruses in heart tissue of DCM patients with and without an IMID. Serum and myocardial tissue samples were obtained from 159 consecutive patients with DCM and 20 controls. Patients were subdivided into three groups, the first two based on the presence (n = 34) or absence (n = 125) of an IMID and the third being a control group. The parvovirus B19 virus genome was detected in equal quantities in the non-IMID DCM patients (100/125) and the control group (15/20) but in lower quantities in the IMID patients (21/34, P = 0.02). Both the non-IMID and IMID DCM patients demonstrated increased myocardial inflammation compared to controls: 12.5 +/- 1.8 and 14.0 +/- 3.2 CD45-positive inflammatory cells, respectively, versus 5.1 +/- 0.7 for the controls (P
U2 - 10.1128/CVI.00281-12
DO - 10.1128/CVI.00281-12
M3 - Article
C2 - 22695157
SN - 1556-6811
VL - 19
SP - 1182
EP - 1187
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
IS - 8
ER -