Differences in Pulmonary and Extra-Pulmonary Traits between Women and Men with Chronic Obstructive Pulmonary Disease

Sara Souto-Miranda; Alex J van 't Hul; Anouk W Vaes; Jeanine C Antons; Remco S Djamin; Daisy J A Janssen; Frits M E Franssen; Alda Marques; Martijn A Spruit

doi:10.3390/jcm11133680

Differences in Pulmonary and Extra-Pulmonary Traits between Women and Men with Chronic Obstructive Pulmonary Disease

Sara Souto-Miranda^*, Alex J van 't Hul, Anouk W Vaes, Jeanine C Antons, Remco S Djamin, Daisy J A Janssen, Frits M E Franssen, Alda Marques, Martijn A Spruit

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Evidence suggests sex-related differences in chronic obstructive pulmonary disease (COPD). Whether these differences are reflected in the prevalence of treatable traits remains unknown.

METHODS: Two samples of patients referred to secondary (n = 530) or tertiary care (n = 2012) were analyzed. Men and women were matched for age, forced expiratory volume in 1 s and body mass index. Sex-related differences were tested using t-tests, Mann-Whitney U, or chi-square tests.

RESULTS: Frequent exacerbations (30.5 vs. 19.7%), high cardiovascular risk (88.1 vs. 66.2%) and activity-related severe dyspnea (50.9 vs. 34.8%) were more prevalent in women in secondary care (p < 0.05). Severe hyperinflation (43.0 vs. 25.4%), limited diffusing capacity (79.6 vs. 70.1%), impaired mobility (44.0 vs. 28.7%), frequent exacerbations (66.8 vs. 57.4%), frequent hospitalizations (47.5 vs. 41.6%), severe activity-related dyspnea (89.1 vs. 85.0%), symptoms of anxiety (56.3 vs. 42.0%) and depression (50.3 vs. 44.8%), and poor health status (79.9 vs. 71.0%) were more prevalent in women in tertiary care (p < 0.05). Severe inspiratory muscle weakness (14.6 vs. 8.2%) and impaired exercise capacity (69.1 vs. 59.6%) were more prevalent among men (p < 0.05) in tertiary care.

CONCLUSIONS: Sex-related differences were found, with most traits more prevalent and severe among women. Care providers should be aware of these differences to adjust treatment.

Original language	English
Article number	3680
Number of pages	15
Journal	Journal of Clinical Medicine
Volume	11
Issue number	13
DOIs	https://doi.org/10.3390/jcm11133680
Publication status	Published - 26 Jun 2022

Keywords

COPD
sex-related differences
gender
treatable traits
THORACIC SOCIETY
HOSPITAL ANXIETY
GENDER
DEPRESSION
SYMPTOMS
REHABILITATION
MANAGEMENT
RISK
SEX

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Cite this

@article{7f94eeac19e14c1387bfde087bfaccef,

title = "Differences in Pulmonary and Extra-Pulmonary Traits between Women and Men with Chronic Obstructive Pulmonary Disease",

abstract = "BACKGROUND: Evidence suggests sex-related differences in chronic obstructive pulmonary disease (COPD). Whether these differences are reflected in the prevalence of treatable traits remains unknown.METHODS: Two samples of patients referred to secondary (n = 530) or tertiary care (n = 2012) were analyzed. Men and women were matched for age, forced expiratory volume in 1 s and body mass index. Sex-related differences were tested using t-tests, Mann-Whitney U, or chi-square tests.RESULTS: Frequent exacerbations (30.5 vs. 19.7%), high cardiovascular risk (88.1 vs. 66.2%) and activity-related severe dyspnea (50.9 vs. 34.8%) were more prevalent in women in secondary care (p < 0.05). Severe hyperinflation (43.0 vs. 25.4%), limited diffusing capacity (79.6 vs. 70.1%), impaired mobility (44.0 vs. 28.7%), frequent exacerbations (66.8 vs. 57.4%), frequent hospitalizations (47.5 vs. 41.6%), severe activity-related dyspnea (89.1 vs. 85.0%), symptoms of anxiety (56.3 vs. 42.0%) and depression (50.3 vs. 44.8%), and poor health status (79.9 vs. 71.0%) were more prevalent in women in tertiary care (p < 0.05). Severe inspiratory muscle weakness (14.6 vs. 8.2%) and impaired exercise capacity (69.1 vs. 59.6%) were more prevalent among men (p < 0.05) in tertiary care.CONCLUSIONS: Sex-related differences were found, with most traits more prevalent and severe among women. Care providers should be aware of these differences to adjust treatment.",

keywords = "COPD, sex-related differences, gender, treatable traits, THORACIC SOCIETY, HOSPITAL ANXIETY, GENDER, DEPRESSION, SYMPTOMS, REHABILITATION, MANAGEMENT, RISK, SEX",

author = "Sara Souto-Miranda and {van 't Hul}, {Alex J} and Vaes, {Anouk W} and Antons, {Jeanine C} and Djamin, {Remco S} and Janssen, {Daisy J A} and Franssen, {Frits M E} and Alda Marques and Spruit, {Martijn A}",

note = "Funding Information: Funding: This work was funded by the Ciro + Short-term Research Training Fellowship 2021 and by Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia (FCT) through the European Social Fund and Pro-grama Operacional Regional do Centro, under the Ph.D. grant SFRH/BD/146134/2019 and project UIDB/04501/2020. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "26",

doi = "10.3390/jcm11133680",

language = "English",

volume = "11",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "13",

}

TY - JOUR

T1 - Differences in Pulmonary and Extra-Pulmonary Traits between Women and Men with Chronic Obstructive Pulmonary Disease

AU - Souto-Miranda, Sara

AU - van 't Hul, Alex J

AU - Vaes, Anouk W

AU - Antons, Jeanine C

AU - Djamin, Remco S

AU - Janssen, Daisy J A

AU - Franssen, Frits M E

AU - Marques, Alda

AU - Spruit, Martijn A

N1 - Funding Information: Funding: This work was funded by the Ciro + Short-term Research Training Fellowship 2021 and by Fundação para a Ciência e a Tecnologia (FCT) through the European Social Fund and Pro-grama Operacional Regional do Centro, under the Ph.D. grant SFRH/BD/146134/2019 and project UIDB/04501/2020. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/6/26

Y1 - 2022/6/26

N2 - BACKGROUND: Evidence suggests sex-related differences in chronic obstructive pulmonary disease (COPD). Whether these differences are reflected in the prevalence of treatable traits remains unknown.METHODS: Two samples of patients referred to secondary (n = 530) or tertiary care (n = 2012) were analyzed. Men and women were matched for age, forced expiratory volume in 1 s and body mass index. Sex-related differences were tested using t-tests, Mann-Whitney U, or chi-square tests.RESULTS: Frequent exacerbations (30.5 vs. 19.7%), high cardiovascular risk (88.1 vs. 66.2%) and activity-related severe dyspnea (50.9 vs. 34.8%) were more prevalent in women in secondary care (p < 0.05). Severe hyperinflation (43.0 vs. 25.4%), limited diffusing capacity (79.6 vs. 70.1%), impaired mobility (44.0 vs. 28.7%), frequent exacerbations (66.8 vs. 57.4%), frequent hospitalizations (47.5 vs. 41.6%), severe activity-related dyspnea (89.1 vs. 85.0%), symptoms of anxiety (56.3 vs. 42.0%) and depression (50.3 vs. 44.8%), and poor health status (79.9 vs. 71.0%) were more prevalent in women in tertiary care (p < 0.05). Severe inspiratory muscle weakness (14.6 vs. 8.2%) and impaired exercise capacity (69.1 vs. 59.6%) were more prevalent among men (p < 0.05) in tertiary care.CONCLUSIONS: Sex-related differences were found, with most traits more prevalent and severe among women. Care providers should be aware of these differences to adjust treatment.

AB - BACKGROUND: Evidence suggests sex-related differences in chronic obstructive pulmonary disease (COPD). Whether these differences are reflected in the prevalence of treatable traits remains unknown.METHODS: Two samples of patients referred to secondary (n = 530) or tertiary care (n = 2012) were analyzed. Men and women were matched for age, forced expiratory volume in 1 s and body mass index. Sex-related differences were tested using t-tests, Mann-Whitney U, or chi-square tests.RESULTS: Frequent exacerbations (30.5 vs. 19.7%), high cardiovascular risk (88.1 vs. 66.2%) and activity-related severe dyspnea (50.9 vs. 34.8%) were more prevalent in women in secondary care (p < 0.05). Severe hyperinflation (43.0 vs. 25.4%), limited diffusing capacity (79.6 vs. 70.1%), impaired mobility (44.0 vs. 28.7%), frequent exacerbations (66.8 vs. 57.4%), frequent hospitalizations (47.5 vs. 41.6%), severe activity-related dyspnea (89.1 vs. 85.0%), symptoms of anxiety (56.3 vs. 42.0%) and depression (50.3 vs. 44.8%), and poor health status (79.9 vs. 71.0%) were more prevalent in women in tertiary care (p < 0.05). Severe inspiratory muscle weakness (14.6 vs. 8.2%) and impaired exercise capacity (69.1 vs. 59.6%) were more prevalent among men (p < 0.05) in tertiary care.CONCLUSIONS: Sex-related differences were found, with most traits more prevalent and severe among women. Care providers should be aware of these differences to adjust treatment.

KW - COPD

KW - sex-related differences

KW - gender

KW - treatable traits

KW - THORACIC SOCIETY

KW - HOSPITAL ANXIETY

KW - GENDER

KW - DEPRESSION

KW - SYMPTOMS

KW - REHABILITATION

KW - MANAGEMENT

KW - RISK

KW - SEX

U2 - 10.3390/jcm11133680

DO - 10.3390/jcm11133680

M3 - Article

C2 - 35806965

SN - 2077-0383

VL - 11

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 13

M1 - 3680

ER -