TY - JOUR
T1 - Differences between liking and wanting signals in the human brain and relations with cognitive dietary restraint and body mass index.
AU - Born, J.M.
AU - Lemmens, S.G.
AU - Martens, M.
AU - Formisano, E.
AU - Goebel, R.
AU - Westerterp-Plantenga, M.S.
PY - 2011/8
Y1 - 2011/8
N2 - BACKGROUND: Eating behavior is determined, to a significant extent, by the rewarding value of food (ie, liking and wanting). OBJECTIVE: We determined brain regions involved in liking and wanting and related brain signaling to body mass index (BMI; in kg/m(2)) and dietary restraint. DESIGN: Fifteen normal-weight female subjects [mean +/- SEM age: 21.5 +/- 0.4 y; BMI: 22.2 +/- 0.2] completed a food-choice paradigm by using visually displayed food items during functional magnetic resonance imaging (fMRI) scans. Two scans were made as follows: one scan was made in a fasted condition, and one scan was made in a satiated condition. The paradigm discriminated between liking and wanting, and subjects were offered items rated highly for wanting immediately after each scan. Imaging contrasts for high and low liking and wanting were made, and data for regions of interest were extracted. Activation related to liking and wanting, respectively, was determined. Outcomes were correlated to cognitive dietary restraint and BMI. RESULTS: Dietary restraint predicted liking task-related signaling (TRS) in the amygdala, striatum, thalamus, and cingulate cortex (r = -0.5 +/- 0.03, P < 0.00001). In the nucleus accumbens, the premeal liking and wanting TRS and premeal to postmeal liking TRS changes correlated positively with dietary restraint [bilateral average r = 0.6 +/- 0.02, P < 0.04 (Bonferroni corrected)]. BMI and hunger predicted wanting TRS in the hypothalamus and striatum (P < 0.05). Postmeal liking TRS in the striatum, anterior insula, and cingulate cortex and wanting TRS in the striatum predicted the energy intake (liking: r = -0.3 +/- 0.05, P < 0.0001; wanting: r = -0.3 +/- 0.03, P < 0.00001). CONCLUSIONS: Successful dietary restraint was supported by liking TRS from premeal to postmeal in the nucleus accumbens. Reward-related signaling was inversely related to BMI and energy intake, indicating reward deficiency.
AB - BACKGROUND: Eating behavior is determined, to a significant extent, by the rewarding value of food (ie, liking and wanting). OBJECTIVE: We determined brain regions involved in liking and wanting and related brain signaling to body mass index (BMI; in kg/m(2)) and dietary restraint. DESIGN: Fifteen normal-weight female subjects [mean +/- SEM age: 21.5 +/- 0.4 y; BMI: 22.2 +/- 0.2] completed a food-choice paradigm by using visually displayed food items during functional magnetic resonance imaging (fMRI) scans. Two scans were made as follows: one scan was made in a fasted condition, and one scan was made in a satiated condition. The paradigm discriminated between liking and wanting, and subjects were offered items rated highly for wanting immediately after each scan. Imaging contrasts for high and low liking and wanting were made, and data for regions of interest were extracted. Activation related to liking and wanting, respectively, was determined. Outcomes were correlated to cognitive dietary restraint and BMI. RESULTS: Dietary restraint predicted liking task-related signaling (TRS) in the amygdala, striatum, thalamus, and cingulate cortex (r = -0.5 +/- 0.03, P < 0.00001). In the nucleus accumbens, the premeal liking and wanting TRS and premeal to postmeal liking TRS changes correlated positively with dietary restraint [bilateral average r = 0.6 +/- 0.02, P < 0.04 (Bonferroni corrected)]. BMI and hunger predicted wanting TRS in the hypothalamus and striatum (P < 0.05). Postmeal liking TRS in the striatum, anterior insula, and cingulate cortex and wanting TRS in the striatum predicted the energy intake (liking: r = -0.3 +/- 0.05, P < 0.0001; wanting: r = -0.3 +/- 0.03, P < 0.00001). CONCLUSIONS: Successful dietary restraint was supported by liking TRS from premeal to postmeal in the nucleus accumbens. Reward-related signaling was inversely related to BMI and energy intake, indicating reward deficiency.
KW - ORBITOFRONTAL CORTEX
KW - WEIGHT MAINTENANCE
KW - REWARD SYSTEMS
KW - ACUTE STRESS
KW - FOOD
KW - DOPAMINE
KW - APPETITE
KW - OBESITY
KW - HUNGER
KW - SENSITIVITY
U2 - 10.3945/ajcn.111.012161
DO - 10.3945/ajcn.111.012161
M3 - Article
C2 - 21653801
SN - 0002-9165
VL - 94
SP - 392
EP - 403
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 2
ER -