@article{c1bc99a57f9342feaca544d19c43dea7,
title = "Differences between HbA1c and glucose-related variables in predicting weight loss and glycaemic changes in individuals with overweight and hyperglycaemia- The PREVIEW trial",
abstract = "Aims: To examine the differences between HbA 1c and glucose related variables in predicting weight loss and glycaemic changes following 8 weeks of low energy diet (LED) in individuals with overweight and hyperglycaemia. Research design and methods: 2178 individuals with ADA-defined pre-diabetes - impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) - who started an 8 week LED weight loss diet, were included in this analysis. Participants were enrolled in the PREVIEW (PREVention of diabetes through lifestyle interventions and population studies In Europe and around the World) clinical trial. Multivariable linear mixed effects regression models and generalised additive mixed effect logistic models were used. Results: Only 1 in 3 participants (33%) had HbA 1c levels defined as pre-diabetes. Neither baseline HbA 1c, IFG or IGT were associated with body weight change at 8 weeks. Higher baseline body weight, baseline fasting insulin and weight loss predicted normalisation of fasting plasma glucose (FPG), whilst higher baseline fasting insulin, C-reactive protein (hsCRP) and older age predicted normalisation of HbA 1c. Additionally, male sex and higher baseline BMI, body fat and energy intake were positively associated with weight loss, whereas greater age and higher HDL-cholesterol predicted less weight loss. Conclusions: Whilst neither HbA 1c nor fasting glucose predicts short-term weight loss success, both may impact the metabolic response to rapid weight loss. We propose a role of inflammation versus total body adiposity since these variables are independent predictors of the normalisation of HbA 1c and fasting glucose, respectively.",
keywords = "C-REACTIVE PROTEIN, DIAGNOSIS, DIET, HEMOGLOBIN A1C, HemoglobinA1c, INFLAMMATION, INSULIN-RESISTANCE, INTERLEUKIN-6, Impaired fasting glucose, Impaired glucose tolerance, LIPOPOLYSACCHARIDE, Prediabetes, SECRETION, TOLERANCE, Weight loss, reduction, Reduction",
author = "M.P. Silvestre and M. Fogelholm and M. Alves and A. Papoila and T. Adam and A.M.Y. Liu and J. Brand-Miller and M. Westerterp-Plantenga and T. Handjieva-Darlenska and I.A. Macdonald and R.X. Zhu and E. Jalo and R. Muirhead and S.N. Carretero and S. Handjiev and M.A. Taylor and A. Raben and S.D. Poppitt",
note = "Funding Information: The PREVIEW consortium would like to thank all study participants at every intervention centre for their time and commitment and all scientists, advisors, and students for their dedication and contributions to the study. The funding sources are as follows: EU framework programme 7 (FP7/2007–2013) grant agreement # 312057 . National Health and Medical Research Council - EU Collaborative Grant, AUS 8, ID 1067711 ). The Glycemic Index Foundation Australia through royalties to the University of Sydney . The New Zealand Health Research Council (grant #14/191 ) and University of Auckland Faculty Research Development Fund . The Cambridge Weight Plan {\textcopyright} donated all products for the 8-weeks weight loss period. The Danish Agriculture & Food Council . The Danish Meat and Research Institute . National Institute for Health Research Biomedical Research Centre (NIHR BRC) (UK). Biotechnology and Biological Sciences Research Council (BBSRC) (UK). Engineering and Physical Sciences Research Council (EPSRC) (UK). Nutritics (Dublin) donated all dietary analyses software used by UNOTT . Juho Vainio Foundation (FIN), Academy of Finland (grant numbers: 272376 , 314383 , 266286 , 314135 ), Finnish Medical Foundation, Gyllenberg Foundation , Novo Nordisk Foundation , Finnish Diabetes Research Foundation , University of Helsinki, Government Research Funds for Helsinki University Hospital (FIN), Jenny and Antti Wihuri Foundation (FIN), Emil Aaltonen Foundation (FIN). China Scholarship Council . Funding Information: The PREVIEW consortium would like to thank all study participants at every intervention centre for their time and commitment and all scientists, advisors, and students for their dedication and contributions to the study. The funding sources are as follows: EU framework programme 7 (FP7/2007–2013) grant agreement # 312057. National Health and Medical Research Council - EU Collaborative Grant, AUS 8, ID 1067711). The Glycemic Index Foundation Australia through royalties to the University of Sydney. The New Zealand Health Research Council (grant #14/191) and University of Auckland Faculty Research Development Fund. The Cambridge Weight Plan{\textcopyright} donated all products for the 8-weeks weight loss period. The Danish Agriculture & Food Council. The Danish Meat and Research Institute. National Institute for Health Research Biomedical Research Centre (NIHR BRC) (UK). Biotechnology and Biological Sciences Research Council (BBSRC) (UK). Engineering and Physical Sciences Research Council (EPSRC) (UK). Nutritics (Dublin) donated all dietary analyses software used by UNOTT. Juho Vainio Foundation (FIN), Academy of Finland (grant numbers: 272376, 314383, 266286, 314135), Finnish Medical Foundation, Gyllenberg Foundation, Novo Nordisk Foundation, Finnish Diabetes Research Foundation, University of Helsinki, Government Research Funds for Helsinki University Hospital (FIN), Jenny and Antti Wihuri Foundation (FIN), Emil Aaltonen Foundation (FIN). China Scholarship Council. Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism",
year = "2023",
month = may,
day = "1",
doi = "10.1016/j.clnu.2023.02.023",
language = "English",
volume = "42",
pages = "636--643",
journal = "Clinical Nutrition",
issn = "0261-5614",
publisher = "Churchill Livingstone",
number = "5",
}