TY - JOUR
T1 - Differences and Similarities Among COVID-19 Patients Treated in Seven ICUs in Three Countries Within One Region
T2 - An Observational Cohort Study
AU - Mesotten, Dieter
AU - Meijs, Daniek A M
AU - van Bussel, Bas C T
AU - Stessel, Björn
AU - Mehagnoul-Schipper, Jannet
AU - Hana, Anisa
AU - Scheeren, Clarissa I E
AU - Strauch, Ulrich
AU - van de Poll, Marcel C G
AU - Ghossein-Doha, Chahinda
AU - Buhre, Wolfgang F F A
AU - Bickenbach, Johannes
AU - Vander Laenen, Margot
AU - Marx, Gernot
AU - van der Horst, Iwan C C
AU - COVID Data Platform (CoDaP) Investigators
N1 - Copyright © by 2021 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
PY - 2022/4
Y1 - 2022/4
N2 - OBJECTIVES: To investigate healthcare system-driven variation in general characteristics, interventions, and outcomes in coronavirus disease 2019 (COVID-19) patients admitted to the ICU within one Western European region across three countries.DESIGN: Multicenter observational cohort study.SETTING: Seven ICUs in the Euregio Meuse-Rhine, one region across Belgium, The Netherlands, and Germany.PATIENTS: Consecutive COVID-19 patients supported in the ICU during the first pandemic wave.INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: Baseline demographic and clinical characteristics, laboratory values, and outcome data were retrieved after ethical approval and data-sharing agreements. Descriptive statistics were performed to investigate country-related practice variation. From March 2, 2020, to August 12, 2020, 551 patients were admitted. Mean age was 65.4 ± 11.2 years, and 29% were female. At admission, Acute Physiology and Chronic Health Evaluation II scores were 15.0 ± 5.5, 16.8 ± 5.5, and 15.8 ± 5.3 (p = 0.002), and Sequential Organ Failure Assessment scores were 4.4 ± 2.7, 7.4 ± 2.2, and 7.7 ± 3.2 (p < 0.001) in the Belgian, Dutch, and German parts of Euregio, respectively. The ICU mortality rate was 22%, 42%, and 44%, respectively (p < 0.001). Large differences were observed in the frequency of organ support, antimicrobial/inflammatory therapy application, and ICU capacity. Mixed-multivariable logistic regression analyses showed that differences in ICU mortality were independent of age, sex, disease severity, comorbidities, support strategies, therapies, and complications.CONCLUSIONS: COVID-19 patients admitted to ICUs within one region, the Euregio Meuse-Rhine, differed significantly in general characteristics, applied interventions, and outcomes despite presumed genetic and socioeconomic background, admission diagnosis, access to international literature, and data collection are similar. Variances in healthcare systems' organization, particularly ICU capacity and admission criteria, combined with a rapidly spreading pandemic might be important drivers for the observed differences. Heterogeneity between patient groups but also healthcare systems should be presumed to interfere with outcomes in coronavirus disease 2019.
AB - OBJECTIVES: To investigate healthcare system-driven variation in general characteristics, interventions, and outcomes in coronavirus disease 2019 (COVID-19) patients admitted to the ICU within one Western European region across three countries.DESIGN: Multicenter observational cohort study.SETTING: Seven ICUs in the Euregio Meuse-Rhine, one region across Belgium, The Netherlands, and Germany.PATIENTS: Consecutive COVID-19 patients supported in the ICU during the first pandemic wave.INTERVENTIONS: None.MEASUREMENTS AND MAIN RESULTS: Baseline demographic and clinical characteristics, laboratory values, and outcome data were retrieved after ethical approval and data-sharing agreements. Descriptive statistics were performed to investigate country-related practice variation. From March 2, 2020, to August 12, 2020, 551 patients were admitted. Mean age was 65.4 ± 11.2 years, and 29% were female. At admission, Acute Physiology and Chronic Health Evaluation II scores were 15.0 ± 5.5, 16.8 ± 5.5, and 15.8 ± 5.3 (p = 0.002), and Sequential Organ Failure Assessment scores were 4.4 ± 2.7, 7.4 ± 2.2, and 7.7 ± 3.2 (p < 0.001) in the Belgian, Dutch, and German parts of Euregio, respectively. The ICU mortality rate was 22%, 42%, and 44%, respectively (p < 0.001). Large differences were observed in the frequency of organ support, antimicrobial/inflammatory therapy application, and ICU capacity. Mixed-multivariable logistic regression analyses showed that differences in ICU mortality were independent of age, sex, disease severity, comorbidities, support strategies, therapies, and complications.CONCLUSIONS: COVID-19 patients admitted to ICUs within one region, the Euregio Meuse-Rhine, differed significantly in general characteristics, applied interventions, and outcomes despite presumed genetic and socioeconomic background, admission diagnosis, access to international literature, and data collection are similar. Variances in healthcare systems' organization, particularly ICU capacity and admission criteria, combined with a rapidly spreading pandemic might be important drivers for the observed differences. Heterogeneity between patient groups but also healthcare systems should be presumed to interfere with outcomes in coronavirus disease 2019.
KW - CASE-FATALITY
KW - CORONAVIRUS DISEASE 2019
KW - OUTCOMES
KW - SEX-DIFFERENCES
KW - coronavirus disease 2019
KW - critical care
KW - delivery of healthcare
KW - healthcare economics and organizations
KW - intensive care units
KW - severe acute respiratory syndrome coronavirus 2
U2 - 10.1097/CCM.0000000000005314
DO - 10.1097/CCM.0000000000005314
M3 - Article
C2 - 34636804
SN - 0090-3493
VL - 50
SP - 595
EP - 606
JO - Critical Care Medicine
JF - Critical Care Medicine
IS - 4
ER -