Dietary weight loss-induced changes in RBP4, FFA, and ACE predict weight regain in people with overweight and obesity

Roel G. Vink*, Nadia J. Roumans, Edwin C. Mariman, Marleen A. van Baak

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)

Abstract

Adipokines and other biomarkers were previously identified with roles in energy expenditure, appetite, satiety, and adiposity. Therefore, we investigated whether dietary weight loss-induced changes in adipokines and other biomarkers known to play a role in weight regulation or energy expenditure could predict weight regain in people with overweight and obesity. In this randomized controlled trial 26 males and 30 females (BMI: 28-35 kg/m(2)) followed either a low-calorie diet (LCD; 1250 kcal/day) for 12 weeks or a verylow-calorie diet (VLCD; 500 kcal/day) for 5 weeks followed by a weight stable period of 4 weeks (dietary intervention (DI) period) and a 9-month follow-up period. Blood samples were taken before and after each period to measure FFA, TAG, total cholesterol, insulin, glucose, angiotensin-converting enzyme (ACE) activity, IL-6, RBP4, apelin, leptin, adiponectin, vaspin, and nesfatin-1 concentrations. Weight loss was similar between groups (LCD: -8.2 +/- 0.5 kg; VLCD: -8.9 +/- 0.4 kg, P = 0.30). Only changes in ACE activity, FFA and RBP4 concentrations during DI were correlated with weight regain in the whole group (r = -0.299, P = 0.030, r = -0.274, P = 0.047, and r = 0.357, P = 0.008, respectively). Together they explained 28% (r = 0.532) of weight regain variation. Dietary weight loss-induced changes in ACE activity, FFA and RBP4 independently contribute to weight regain prediction.

Original languageEnglish
Article numbere13450
Number of pages11
JournalPhysiological Reports
Volume5
Issue number21
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Adipokines
  • endocrinology
  • obesity
  • weight loss
  • weight regain
  • RENIN-ANGIOTENSIN SYSTEM
  • CHAIN FATTY-ACIDS
  • ENERGY-BALANCE
  • FOOD-INTAKE
  • MAINTENANCE
  • EXPRESSION
  • INSULIN
  • LEPTIN
  • POLYMORPHISMS
  • ADIPOGENESIS

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