Dietary Strategies and Novel Pharmaceutical Approaches Targeting Serum ApoA-I Metabolism: A Systematic Overview

Lotte Smolders, Jogchum Plat, Ronald P. Mensink*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

The incidence of CHD is still increasing, which underscores the need for new preventive and therapeutic approaches to decrease CHD risk. In this respect, increasing apoA-I concentrations may be a promising approach, especially through increasing apoA-I synthesis. This review first provides insight into current knowledge on apoA-I production, clearance, and degradation, followed by a systematic review of dietary and novel pharmacological approaches to target apoA-I metabolism. For this, a systematic search was performed to identify randomized controlled intervention studies that examined effects of whole foods and (non) nutrients on apoA-I metabolism. In addition, novel pharmacological approaches were searched for, which were specifically developed to target apoA-I metabolism. We conclude that both dietary components and pharmacological approaches can be used to increase apoA-I concentrations or functionality. For the dietary components in particular, more knowledge about the underlying mechanisms is necessary, as increasing apoA-I per se does not necessarily translate into a reduced CHD risk.

Original languageEnglish
Article number5415921
Number of pages28
JournalJournal of Nutrition and Metabolism
DOIs
Publication statusPublished - 2017

Keywords

  • APOLIPOPROTEIN-A-I
  • HIGH-DENSITY-LIPOPROTEIN
  • RANDOMIZED CONTROLLED-TRIAL
  • CORONARY-ARTERY-DISEASE
  • POLYUNSATURATED FATTY-ACIDS
  • REVERSE CHOLESTEROL TRANSPORT
  • PLACEBO-CONTROLLED TRIAL
  • MILDLY HYPERCHOLESTEROLEMIC SUBJECTS
  • FAMILIAL COMBINED HYPERLIPIDEMIA
  • FISH-OIL SUPPLEMENTATION

Fingerprint

Dive into the research topics of 'Dietary Strategies and Novel Pharmaceutical Approaches Targeting Serum ApoA-I Metabolism: A Systematic Overview'. Together they form a unique fingerprint.

Cite this