Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy

Miranda Nabben; Joep P. J. Schmitz; Jolita Ciapaite; Carlijn M. P. le Clercq; Natal A. van Riel; Harm R. Haak; Klaas Nicolay; Irenaeus F. M. de Coo; Hubert Smeets; Stephan F. Praet; Luc J. van Loon; Jeanine J. Prompers

doi:10.1152/ajpregu.00264.2016

Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy

Miranda Nabben, Joep P. J. Schmitz, Jolita Ciapaite, Carlijn M. P. le Clercq, Natal A. van Riel, Harm R. Haak, Klaas Nicolay, Irenaeus F. M. de Coo, Hubert Smeets, Stephan F. Praet, Luc J. van Loon, Jeanine J. Prompers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	R689-R701
Number of pages	13
Journal	American Journal of Physiology-regulatory Integrative and Comparative Physiology
Volume	312
Issue number	5
DOIs	https://doi.org/10.1152/ajpregu.00264.2016
Publication status	Published - 1 May 2017

Keywords

mitochondrial myopathy
nitrate
P-31-magnetic resonance spectroscopy
(V) over dot(O2peak)
permeabilized muscle fibers
TIME-TRIAL PERFORMANCE
HUMAN SKELETAL-MUSCLE
NITRIC-OXIDE
INORGANIC NITRATE
O-2 COST
SUPPLEMENTATION
EFFICIENCY
HUMANS
RESPIRATION
CONSUMPTION

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10.1152/ajpregu.00264.2016

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Nabben, M., Schmitz, J. P. J., Ciapaite, J., le Clercq, C. M. P., van Riel, N. A., Haak, H. R., Nicolay, K., de Coo, I. F. M., Smeets, H., Praet, S. F., van Loon, L. J., & Prompers, J. J. (2017). Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy. American Journal of Physiology-regulatory Integrative and Comparative Physiology, 312(5), R689-R701. https://doi.org/10.1152/ajpregu.00264.2016

Nabben, Miranda ; Schmitz, Joep P. J. ; Ciapaite, Jolita ; le Clercq, Carlijn M. P. ; van Riel, Natal A. ; Haak, Harm R. ; Nicolay, Klaas ; de Coo, Irenaeus F. M. ; Smeets, Hubert ; Praet, Stephan F. ; van Loon, Luc J. ; Prompers, Jeanine J. / Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy. In: American Journal of Physiology-regulatory Integrative and Comparative Physiology. 2017 ; Vol. 312, No. 5. pp. R689-R701.

@article{4774a10555d54a87bed17d4ecf3e428b,

title = "Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy",

keywords = "mitochondrial myopathy, nitrate, P-31-magnetic resonance spectroscopy, (V) over dot(O2peak), permeabilized muscle fibers, TIME-TRIAL PERFORMANCE, HUMAN SKELETAL-MUSCLE, NITRIC-OXIDE, INORGANIC NITRATE, O-2 COST, SUPPLEMENTATION, EFFICIENCY, HUMANS, RESPIRATION, CONSUMPTION",

author = "Miranda Nabben and Schmitz, {Joep P. J.} and Jolita Ciapaite and {le Clercq}, {Carlijn M. P.} and {van Riel}, {Natal A.} and Haak, {Harm R.} and Klaas Nicolay and {de Coo}, {Irenaeus F. M.} and Hubert Smeets and Praet, {Stephan F.} and {van Loon}, {Luc J.} and Prompers, {Jeanine J.}",

year = "2017",

month = may,

day = "1",

doi = "10.1152/ajpregu.00264.2016",

language = "English",

volume = "312",

pages = "R689--R701",

journal = "American Journal of Physiology-regulatory Integrative and Comparative Physiology",

issn = "0363-6119",

publisher = "American Physiological Society",

number = "5",

}

Nabben, M, Schmitz, JPJ, Ciapaite, J, le Clercq, CMP, van Riel, NA, Haak, HR, Nicolay, K, de Coo, IFM, Smeets, H, Praet, SF, van Loon, LJ & Prompers, JJ 2017, 'Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy', American Journal of Physiology-regulatory Integrative and Comparative Physiology, vol. 312, no. 5, pp. R689-R701. https://doi.org/10.1152/ajpregu.00264.2016

Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy. / Nabben, Miranda; Schmitz, Joep P. J.; Ciapaite, Jolita; le Clercq, Carlijn M. P.; van Riel, Natal A.; Haak, Harm R.; Nicolay, Klaas; de Coo, Irenaeus F. M.; Smeets, Hubert; Praet, Stephan F.; van Loon, Luc J.; Prompers, Jeanine J.

In: American Journal of Physiology-regulatory Integrative and Comparative Physiology, Vol. 312, No. 5, 01.05.2017, p. R689-R701.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy

AU - Nabben, Miranda

AU - Schmitz, Joep P. J.

AU - Ciapaite, Jolita

AU - le Clercq, Carlijn M. P.

AU - van Riel, Natal A.

AU - Haak, Harm R.

AU - Nicolay, Klaas

AU - de Coo, Irenaeus F. M.

AU - Smeets, Hubert

AU - Praet, Stephan F.

AU - van Loon, Luc J.

AU - Prompers, Jeanine J.

PY - 2017/5/1

Y1 - 2017/5/1

KW - mitochondrial myopathy

KW - nitrate

KW - P-31-magnetic resonance spectroscopy

KW - (V) over dot(O2peak)

KW - permeabilized muscle fibers

KW - TIME-TRIAL PERFORMANCE

KW - HUMAN SKELETAL-MUSCLE

KW - NITRIC-OXIDE

KW - INORGANIC NITRATE

KW - O-2 COST

KW - SUPPLEMENTATION

KW - EFFICIENCY

KW - HUMANS

KW - RESPIRATION

KW - CONSUMPTION

U2 - 10.1152/ajpregu.00264.2016

DO - 10.1152/ajpregu.00264.2016

M3 - Article

VL - 312

SP - R689-R701

JO - American Journal of Physiology-regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology-regulatory Integrative and Comparative Physiology

SN - 0363-6119

IS - 5

ER -