TY - JOUR
T1 - Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers
T2 - A multinational cohort study
AU - Mayen, Ana-Lucia
AU - Aglago, Elom K.
AU - Knaze, Viktoria
AU - Cordova, Reynalda
AU - Schalkwijk, Casper G.
AU - Wagner, Karl-Heinz
AU - Aleksandrova, Krasimira
AU - Fedirko, Veronika
AU - Keski-Rahkonen, Pekka
AU - Leitzmann, Michael F.
AU - Katzke, Verena
AU - Srour, Bernard
AU - Schulze, Matthias B.
AU - Masala, Giovanna
AU - Krogh, Vittorio
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Bueno-de-Mesquita, Bas
AU - Brustad, Magritt
AU - Agudo, Antonio
AU - Chirlaque Lopez, Maria Dolores
AU - Amiano, Pilar
AU - Ohlsson, Bodil
AU - Ramne, Stina
AU - Aune, Dagfinn
AU - Weiderpass, Elisabete
AU - Jenab, Mazda
AU - Freisling, Heinz
PY - 2021/8/15
Y1 - 2021/8/15
N2 - Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n = 450 111). Dietary intake of three AGEs, N-epsilon-[carboxymethyl]lysine (CML), N-epsilon-[1-carboxyethyl]lysine (CEL) and N-delta-[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with the risk of HCC (per 1 SD increment, HR-(CML) = 0.87, 95% CI: 0.76-0.99, HR-(CEL) = 0.84, 95% CI: 0.74-0.96 and HR-(MH-G1) = 0.84, 95% CI: 0.74-0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-(CML) = 1.28, 95% CI: 1.05-1.56, HR-(CEL) = 1.17; 95% CI: 0.96-1.40, HR-(MH-G1) = 1.27, 95% CI: 1.06-1.54). No associations were observed for cancers of the intra and extrahepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.
AB - Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition prospective cohort (n = 450 111). Dietary intake of three AGEs, N-epsilon-[carboxymethyl]lysine (CML), N-epsilon-[1-carboxyethyl]lysine (CEL) and N-delta-[5-hydro-5-methyl-4-imidazolon-2-yl]-ornithine (MG-H1), was estimated using country-specific dietary questionnaires linked to an AGEs database. Cause-specific hazard ratios (HR) and their 95% confidence intervals (CI) for associations between dietary AGEs and risk of hepatocellular carcinoma (HCC), gallbladder and biliary tract cancers were estimated using multivariable Cox proportional hazard regression. After a median follow-up time of 14.9 years, 255 cases of HCC, 100 cases of gallbladder cancer and 173 biliary tract cancers were ascertained. Higher intakes of dietary AGEs were inversely associated with the risk of HCC (per 1 SD increment, HR-(CML) = 0.87, 95% CI: 0.76-0.99, HR-(CEL) = 0.84, 95% CI: 0.74-0.96 and HR-(MH-G1) = 0.84, 95% CI: 0.74-0.97). In contrast, positive associations were observed with risk of gallbladder cancer (per 1 SD, HR-(CML) = 1.28, 95% CI: 1.05-1.56, HR-(CEL) = 1.17; 95% CI: 0.96-1.40, HR-(MH-G1) = 1.27, 95% CI: 1.06-1.54). No associations were observed for cancers of the intra and extrahepatic bile ducts. Our findings suggest that higher intakes of dietary AGEs are inversely associated with the risk of HCC and positively associated with the risk of gallbladder cancer.
KW - advanced glycation endproducts
KW - bile duct cancers
KW - EPIC study
KW - gallbladder cancer
KW - hepatocellular carcinoma
U2 - 10.1002/ijc.33612
DO - 10.1002/ijc.33612
M3 - Article
C2 - 33899229
VL - 149
SP - 854
EP - 864
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 4
ER -