Dietary Flavonoid Intake, Black Tea Consumption, and Risk of Overall and Advanced Stage Prostate Cancer

Research output: Contribution to journalArticleAcademicpeer-review

27 Citations (Scopus)

Abstract

Flavonoids are natural antioxidants found in various foods, and a major source is black tea. Some experimental evidence indicates that flavonoids could prevent prostate cancer. We investigated the associations between flavonoid intake, black tea consumption, and prostate cancer risk in the Netherlands Cohort study, which includes 58,279 men who provided detailed baseline information on several cancer risk factors. From 1986 to 2003, 3,362 prostate cancers were identified, including 1,164 advanced (stage III/IV) cancers. Cox proportional hazards regression using the case-cohort approach was used to estimate hazard ratios and 95% confidence intervals. Intake of total catechin, epicatechin, kaempferol, and myricetin and consumption of black tea were associated with a decreased risk of stage III/IV or stage IV prostate cancer. Hazard ratios of stage III/IV and stage IV prostate cancer for the highest versus the lowest category of black tea consumption (>/=5 versus </=1 cups/day) were 0.75 (95% confidence interval: 0.59, 0.97) and 0.67 (95% confidence interval: 0.50, 0.91), respectively. No associations were observed for overall and nonadvanced prostate cancer. In conclusion, dietary flavonoid intake and black tea consumption were associated with a decreased risk of advanced stage prostate cancer.
Original languageEnglish
Pages (from-to)1388-1398
Number of pages11
JournalAmerican Journal of Epidemiology
Volume177
Issue number12
DOIs
Publication statusPublished - 15 Jun 2013

Keywords

  • advanced prostate cancer
  • black tea
  • catechins
  • flavonoids
  • flavonols
  • prostate cancer
  • POTENTIALLY ANTICARCINOGENIC FLAVONOIDS
  • SCALE PROSPECTIVE COHORT
  • GREEN-TEA
  • INTRAEPITHELIAL NEOPLASIA
  • CATECHIN CONTENTS
  • DISEASE RISK
  • FRUIT JUICES
  • NETHERLANDS
  • POLYPHENOLS
  • MEN

Cite this

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title = "Dietary Flavonoid Intake, Black Tea Consumption, and Risk of Overall and Advanced Stage Prostate Cancer",
abstract = "Flavonoids are natural antioxidants found in various foods, and a major source is black tea. Some experimental evidence indicates that flavonoids could prevent prostate cancer. We investigated the associations between flavonoid intake, black tea consumption, and prostate cancer risk in the Netherlands Cohort study, which includes 58,279 men who provided detailed baseline information on several cancer risk factors. From 1986 to 2003, 3,362 prostate cancers were identified, including 1,164 advanced (stage III/IV) cancers. Cox proportional hazards regression using the case-cohort approach was used to estimate hazard ratios and 95{\%} confidence intervals. Intake of total catechin, epicatechin, kaempferol, and myricetin and consumption of black tea were associated with a decreased risk of stage III/IV or stage IV prostate cancer. Hazard ratios of stage III/IV and stage IV prostate cancer for the highest versus the lowest category of black tea consumption (>/=5 versus </=1 cups/day) were 0.75 (95{\%} confidence interval: 0.59, 0.97) and 0.67 (95{\%} confidence interval: 0.50, 0.91), respectively. No associations were observed for overall and nonadvanced prostate cancer. In conclusion, dietary flavonoid intake and black tea consumption were associated with a decreased risk of advanced stage prostate cancer.",
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author = "M.S. Geybels and B.A. Verhage and I.C. Arts and {van Schooten}, F.J. and R.A. Goldbohm and {van den Brandt}, P.A.",
year = "2013",
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language = "English",
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Dietary Flavonoid Intake, Black Tea Consumption, and Risk of Overall and Advanced Stage Prostate Cancer. / Geybels, M.S.; Verhage, B.A.; Arts, I.C.; van Schooten, F.J.; Goldbohm, R.A.; van den Brandt, P.A.

In: American Journal of Epidemiology, Vol. 177, No. 12, 15.06.2013, p. 1388-1398.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Dietary Flavonoid Intake, Black Tea Consumption, and Risk of Overall and Advanced Stage Prostate Cancer

AU - Geybels, M.S.

AU - Verhage, B.A.

AU - Arts, I.C.

AU - van Schooten, F.J.

AU - Goldbohm, R.A.

AU - van den Brandt, P.A.

PY - 2013/6/15

Y1 - 2013/6/15

N2 - Flavonoids are natural antioxidants found in various foods, and a major source is black tea. Some experimental evidence indicates that flavonoids could prevent prostate cancer. We investigated the associations between flavonoid intake, black tea consumption, and prostate cancer risk in the Netherlands Cohort study, which includes 58,279 men who provided detailed baseline information on several cancer risk factors. From 1986 to 2003, 3,362 prostate cancers were identified, including 1,164 advanced (stage III/IV) cancers. Cox proportional hazards regression using the case-cohort approach was used to estimate hazard ratios and 95% confidence intervals. Intake of total catechin, epicatechin, kaempferol, and myricetin and consumption of black tea were associated with a decreased risk of stage III/IV or stage IV prostate cancer. Hazard ratios of stage III/IV and stage IV prostate cancer for the highest versus the lowest category of black tea consumption (>/=5 versus </=1 cups/day) were 0.75 (95% confidence interval: 0.59, 0.97) and 0.67 (95% confidence interval: 0.50, 0.91), respectively. No associations were observed for overall and nonadvanced prostate cancer. In conclusion, dietary flavonoid intake and black tea consumption were associated with a decreased risk of advanced stage prostate cancer.

AB - Flavonoids are natural antioxidants found in various foods, and a major source is black tea. Some experimental evidence indicates that flavonoids could prevent prostate cancer. We investigated the associations between flavonoid intake, black tea consumption, and prostate cancer risk in the Netherlands Cohort study, which includes 58,279 men who provided detailed baseline information on several cancer risk factors. From 1986 to 2003, 3,362 prostate cancers were identified, including 1,164 advanced (stage III/IV) cancers. Cox proportional hazards regression using the case-cohort approach was used to estimate hazard ratios and 95% confidence intervals. Intake of total catechin, epicatechin, kaempferol, and myricetin and consumption of black tea were associated with a decreased risk of stage III/IV or stage IV prostate cancer. Hazard ratios of stage III/IV and stage IV prostate cancer for the highest versus the lowest category of black tea consumption (>/=5 versus </=1 cups/day) were 0.75 (95% confidence interval: 0.59, 0.97) and 0.67 (95% confidence interval: 0.50, 0.91), respectively. No associations were observed for overall and nonadvanced prostate cancer. In conclusion, dietary flavonoid intake and black tea consumption were associated with a decreased risk of advanced stage prostate cancer.

KW - advanced prostate cancer

KW - black tea

KW - catechins

KW - flavonoids

KW - flavonols

KW - prostate cancer

KW - POTENTIALLY ANTICARCINOGENIC FLAVONOIDS

KW - SCALE PROSPECTIVE COHORT

KW - GREEN-TEA

KW - INTRAEPITHELIAL NEOPLASIA

KW - CATECHIN CONTENTS

KW - DISEASE RISK

KW - FRUIT JUICES

KW - NETHERLANDS

KW - POLYPHENOLS

KW - MEN

U2 - 10.1093/aje/kws419

DO - 10.1093/aje/kws419

M3 - Article

VL - 177

SP - 1388

EP - 1398

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 12

ER -