Dietary B group vitamin intake and the bladder cancer risk: a pooled analysis of prospective cohort studies

I.W.A. Boot, A. Wesselius*, E.Y.W. Yu, M. Brinkman, P. van den Brandt, E.J. Grant, E. White, E. Weiderpass, P. Ferrari, M.B. Schulze, B. Bueno-de-Mesquita, M. Jose-Sanchez, B. Gylling, M.P. Zeegers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Purpose Diet may play an essential role in the aetiology of bladder cancer (BC). The B group complex vitamins involve diverse biological functions that could be influential in cancer prevention. The aim of the present study was to investigate the association between various components of the B group vitamin complex and BC risk. Methods Dietary data were pooled from four cohort studies. Food item intake was converted to daily intakes of B group vitamins and pooled multivariate hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were obtained using Cox-regression models. Dose-response relationships were examined using a nonparametric test for trend. Results In total, 2915 BC cases and 530,012 non-cases were included in the analyses. The present study showed an increased BC risk for moderate intake of vitamin B1 (HRB1: 1.13, 95% CI: 1.00-1.20). In men, moderate intake of the vitamins B1, B2, energy-related vitamins and high intake of vitamin B1 were associated with an increased BC risk (HR (95% CI): 1.13 (1.02-1.26), 1.14 (1.02-1.26), 1.13 (1.02-1.26; 1.13 (1.02-1.26), respectively). In women, high intake of all vitamins and vitamin combinations, except for the entire complex, showed an inverse association (HR (95% CI): 0.80 (0.67-0.97), 0.83 (0.70-1.00); 0.77 (0.63-0.93), 0.73 (0.61-0.88), 0.82 (0.68-0.99), 0.79 (0.66-0.95), 0.80 (0.66-0.96), 0.74 (0.62-0.89), 0.76 (0.63-0.92), respectively). Dose-response analyses showed an increased BC risk for higher intake of vitamin B1 and B12. Conclusion Our findings highlight the importance of future research on the food sources of B group vitamins in the context of the overall and sex-stratified diet.
Original languageEnglish
Pages (from-to)2397-2416
Number of pages20
JournalEuropean Journal of Nutrition
Issue number5
Early online date7 Feb 2022
Publication statusPublished - Aug 2022


  • Nutritional oncology
  • Bladder cancer
  • Pooled cohort analysis
  • B group vitamins
  • MEAT
  • FOOD

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