Dietary arginine and linear growth: the Copenhagen School Child Intervention Study

Anneke J. A. H. van Vught*, Pieter C. Dagnelie, Ilja C. W. Arts, Karsten Froberg, Lars B. Andersen, Bianca El-Naaman, Anna Bugge, Birgit M. Nielsen, Berit L. Heitman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The amino acid arginine is a well-known growth hormone (GH) stimulator and GH is an important modulator of linear growth. The aim of the present study was to investigate the effect of dietary arginine on growth velocity in children between 7 and 13 years of age. Data from the Copenhagen School Child Intervention Study during 2001-2 (baseline), and at 3-year and 7-year follow-up, were used. Arginine intake was estimated via a 7 d precoded food diary at baseline and 3-year follow-up. Data were analysed in a multilevel structure in which children were embedded within schools. Random intercept and slopes were defined to estimate the association between arginine intake and growth velocity, including the following covariates: sex; age; baseline height; energy intake; puberty stage at 7-year follow-up and intervention/control group. The association between arginine intake and growth velocity was significant for the third and fourth quintile of arginine intake (2.5-2.8 and 2.8-3.2 g/d, respectively) compared with the first quintile (
Original languageEnglish
Pages (from-to)1031-1039
JournalBritish Journal of Nutrition
Issue number6
Publication statusPublished - 28 Mar 2013


  • Arginine
  • Linear growth
  • Growth hormone

Cite this