Diet-induced weight loss improves not only cardiometabolic risk markers but also markers of vascular function: a randomized controlled trial in abdominally obese men

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Abstract

Background: Many trials assessing effects of dietary weight loss on vascular function have been performed without no weight loss control groups and in individuals with obesity-related morbidities. Usually a limited set of vascular function markers has been investigated.

Objective: The objective of this study was to examine effects of diet-induced weight loss on various vascular function markers and differences between normal-weight and abdominally obese men at baseline and after weight reduction.

Design: Twenty-five healthy, normal-weight men (waist circumference:

Results: Compared with the control group, FMD did not change in the weight-loss group, but carotid-to-femoral pulse wave velocity tended to decrease by 0.5 m/s (P = 0.065). The retinal arteriolar caliber increased by 5 mu m (P <0.001) and the arteriolar-to-venular ratio by 0.02 (P <0.01). Soluble endothelial selectin and soluble intercellular adhesion molecule concentrations decreased (P <0.001). Also, total cholesterol, low density lipoprotein cholesterol, triacylglycerol, glucose, insulin, C-peptide, homeostasis model assessment of insulin resistance, and blood pressure improved (P <0.05 for all variables). Except for FMD, these markers differed at baseline between normal-weight and abdominally obese men but became comparable after weight loss.

Conclusions: In abdominally obese men, dietary weight loss targeting a waist circumference of

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume105
Issue number1
DOIs
Publication statusPublished - Jan 2017

Keywords

  • abdominal obesity
  • cardiometabolic risk
  • dietary weight loss
  • flow-mediated vasodilation
  • vascular function
  • FLOW-MEDIATED VASODILATION
  • EXPERT CONSENSUS DOCUMENT
  • CORONARY-ARTERY-DISEASE
  • PULSE-WAVE VELOCITY
  • ENDOTHELIAL FUNCTION
  • CARDIOVASCULAR-DISEASE
  • INSULIN-RESISTANCE
  • METABOLIC SYNDROME
  • FAT DISTRIBUTION
  • BRACHIAL-ARTERY

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