TY - JOUR
T1 - Diet and cognitive decline at middle age: the role of antioxidants
AU - Nooyens, Astrid C. J.
AU - Milder, Ivon E. J.
AU - van Gelder, Boukje M.
AU - Bueno-de-Mesquita, H. Bas
AU - van Boxtel, Martin P. J.
AU - Verschuren, W. M. Monique
PY - 2015/5/14
Y1 - 2015/5/14
N2 - To assess the relationship between dietary intake of antioxidants (vitamin C, vitamin E, -carotene, lutein, flavonoids and lignans) and cognitive decline at middle age, analyses were performed on data from the population based Doetinchem Cohort Study. Habitual diet and cognitive function were assessed twice with a 5-year interval in 2613 persons aged 43-70 year at baseline (1995-2002). Diet was assessed with a validated 178-item semi-quantitative FFQ. Cognitive function was assessed with a neuropsychological test battery, consisting of the 15 Words Learning Test, the Stroop Test, the Word Fluency test, and the Letter Digit Substitution Test. Scores on global cognitive function, memory, processing speed, and cognitive flexibility were calculated. In regression analyses, quintiles of antioxidant intake were associated with change in cognitive domain scores. Results showed that higher lignan intake was linearly associated with less decline in global cognitive function (P=0.01), memory (P
AB - To assess the relationship between dietary intake of antioxidants (vitamin C, vitamin E, -carotene, lutein, flavonoids and lignans) and cognitive decline at middle age, analyses were performed on data from the population based Doetinchem Cohort Study. Habitual diet and cognitive function were assessed twice with a 5-year interval in 2613 persons aged 43-70 year at baseline (1995-2002). Diet was assessed with a validated 178-item semi-quantitative FFQ. Cognitive function was assessed with a neuropsychological test battery, consisting of the 15 Words Learning Test, the Stroop Test, the Word Fluency test, and the Letter Digit Substitution Test. Scores on global cognitive function, memory, processing speed, and cognitive flexibility were calculated. In regression analyses, quintiles of antioxidant intake were associated with change in cognitive domain scores. Results showed that higher lignan intake was linearly associated with less decline in global cognitive function (P=0.01), memory (P
KW - Antioxidants
KW - Cognitive decline
KW - Cohort studies
KW - Middle-aged populations
U2 - 10.1017/S0007114515000720
DO - 10.1017/S0007114515000720
M3 - Article
C2 - 25851267
SN - 0007-1145
VL - 113
SP - 1410
EP - 1417
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 9
ER -