TY - JOUR
T1 - Did age at surgery influence outcome in patients with Hirschsprung disease?
T2 - a nationwide cohort study in the Netherlands
AU - Roorda, Daniëlle
AU - Verkuij, Sanne J
AU - Derikx, Joep P M
AU - Trzpis, Monika
AU - Meinds, Rob J
AU - Sloots, Cornelius E J
AU - Witvliet, Marieke J
AU - de Blaauw, Ivo
AU - van Gemert, Wim G
AU - van Heurn, Lodewijk W E
AU - Broens, Paul M A
N1 - Copyright © 2022 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
PY - 2022/10
Y1 - 2022/10
N2 - OBJECTIVES: Hirschsprung disease (HD) requires surgical resection of affected bowel, but the current evidence is inconclusive regarding the optimal age for resection. The aim of this study was to assess whether age at resection of the aganglionic segment is a determinant for surgical outcomes.METHODS: A cross-sectional cohort study was done including all consecutive patients with HD between 1957 and 2015, aged eight years or older (n=830), who were treated in one of the six pediatric surgical centers in the Netherlands. Outcome measures were mortality, postoperative complications, ostomy rate and redo surgery rate, retrieved from the medical records. Additionally, constipation and fecal incontinence rate in long term were assessed with the Defecation and Continence Questionnaire (DeFeC and P-DeFeC).RESULTS: The medical records of 830 patients were reviewed, and 346 of the 619 eligible patients responded to the follow-up questionnaires (56%). There was a small increase in the risk of a permanent stoma (Odds Ratio (OR) 1.01 [95% CI: 1.00 -1.02], p=0.019) and a temporary stoma (OR 1.01, [95% CI: 1.00 -1.01], p=0.022) with increasing age at surgery, regardless of the length of the aganglionic segment and operation technique. Both adjusted and unadjusted for operation technique, length of disease, and temporary stoma, age at surgery was not associated with the probability and the severity of constipation and fecal incontinence in long term.CONCLUSIONS: In this study we found no evidence that the age at surgery influences surgical outcomes, thus no optimal timing for surgery for HD could be determined.An infographic is available for this article at: http://links.lww.com/MPG/C871.
AB - OBJECTIVES: Hirschsprung disease (HD) requires surgical resection of affected bowel, but the current evidence is inconclusive regarding the optimal age for resection. The aim of this study was to assess whether age at resection of the aganglionic segment is a determinant for surgical outcomes.METHODS: A cross-sectional cohort study was done including all consecutive patients with HD between 1957 and 2015, aged eight years or older (n=830), who were treated in one of the six pediatric surgical centers in the Netherlands. Outcome measures were mortality, postoperative complications, ostomy rate and redo surgery rate, retrieved from the medical records. Additionally, constipation and fecal incontinence rate in long term were assessed with the Defecation and Continence Questionnaire (DeFeC and P-DeFeC).RESULTS: The medical records of 830 patients were reviewed, and 346 of the 619 eligible patients responded to the follow-up questionnaires (56%). There was a small increase in the risk of a permanent stoma (Odds Ratio (OR) 1.01 [95% CI: 1.00 -1.02], p=0.019) and a temporary stoma (OR 1.01, [95% CI: 1.00 -1.01], p=0.022) with increasing age at surgery, regardless of the length of the aganglionic segment and operation technique. Both adjusted and unadjusted for operation technique, length of disease, and temporary stoma, age at surgery was not associated with the probability and the severity of constipation and fecal incontinence in long term.CONCLUSIONS: In this study we found no evidence that the age at surgery influences surgical outcomes, thus no optimal timing for surgery for HD could be determined.An infographic is available for this article at: http://links.lww.com/MPG/C871.
U2 - 10.1097/MPG.0000000000003550
DO - 10.1097/MPG.0000000000003550
M3 - Article
C2 - 35830738
SN - 0277-2116
VL - 75
SP - 431
EP - 437
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 4
ER -