@article{9bf45c9491664d619a3449293f9af756,
title = "Dichotomy between the transcriptomic landscape of naturally versus accelerated aged murine hearts",
abstract = "We investigated the transcriptomic landscape of the murine myocardium along the course of natural aging and in three distinct mouse models of premature aging with established aging-related cardiac dysfunction. Genome-wide total RNA-seq was performed and the expression patterns of protein-coding genes and non-coding RNAs were compared between hearts from naturally aging mice, mice with cardiac-specific deficiency of a component of the DNA repair machinery, mice with reduced mitochondrial antioxidant capacity and mice with reduced telomere length. Our results demonstrate that no dramatic changes are evident in the transcriptomes of naturally senescent murine hearts until two years of age, in contrast to the transcriptome of accelerated aged mice. Additionally, these mice displayed model-specific alterations of the expression levels of protein-coding and non-coding genes with hardly any overlap with age-related signatures. Our data demonstrate very limited similarities between the transcriptomes of all our murine aging models and question their reliability to study human cardiovascular senescence.",
keywords = "NUCLEAR ABNORMALITIES, TELOMERE LENGTH, DNA-DAMAGE, MECHANISMS, CANCER, EXPRESSION, LONGEVITY, PREDICTS, MUTATION, FAILURE",
author = "{De Majo}, Federica and Jana-Charlotte Hegenbarth and Frank Ruehle and Christian Baer and Thomas Thum and {de Boer}, Martine and Duncker, {Dirk J.} and Blanche Schroen and Anne-Sophie Armand and Monika Stoll and {De Windt}, {Leon J.}",
note = "Funding Information: T.T. was supported by ERC Consolidator Grant LONGHEART, by ERA-CVD JCT2016 EXPERT and the DFG (TH903/22-1). C.B. was supported by the DFG (BA5631/2–1) and ERA-CVD JCT2016 EXPERT. D.J.D. acknowledges support from the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, ZonMW and the Royal Netherlands Academy of Sciences (CVON2011-ARENA and CVON2017-ARENA PRIME). A.S.A. was funded by Association Fran{\c c}aise contres les Myopathies (AFM 18802) L.D.W. and F.D.M. are supported by ERA-CVD JCT2016 EXPERT. L.D.W. acknowledges support from the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, ZonMW and the Royal Netherlands Academy of Sciences (CVON2017-ARENA PRIME). L.D.W. was further supported by ERC Consolidator Grant 311549 CALMIRS and a VICI award 918-156-47 from NWO. B.S. is supported by VIDI award 917.14.363 from NWO, Dekker grant 2014T105 from the Dutch Heart Foundation; further support comes from the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, ZonMW and the Royal Netherlands Academy of Sciences (CVON2018 SHE-PREDICTS-HF), and a grant by the Health Foundation Limburg. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
year = "2020",
month = may,
day = "18",
doi = "10.1038/s41598-020-65115-9",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}