Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and niRNAs of NMDA receptor subunits in mouse models of depression

Brandon H. Cline, Joao P. Costa-Nunes, Raymond Cespuglio, Natalyia Markova, Ana I. Santos, Yury V. Bukhman, Aslan Kubatiev, Harry W. M. Steinbusch, Klaus-Peter Lesch, Tatyana Strekalova*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Web of Science)
Original languageEnglish
Article number37
JournalFrontiers in Behavioral Neuroscience
Publication statusPublished - 26 Feb 2015


  • chronic stress
  • insulin receptor
  • dicholine succinate
  • phosphorylated glycogen synthase kinase-3beta (pGSK-3beta)
  • NMDA receptor subunits NR2A and NR2B
  • sleep EEG
  • aging
  • hippocampal plasticity

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