@article{c73da1a22f8b4d61a3cd4ce5630709d7,
title = "Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study",
abstract = "Aims We studied the association of circulating metabolic biomarkers with asymptomatic left ventricular diastolic dysfunction, a risk-carrying condition that affects 25\% of the population. Methods and results In 570 randomly recruited people, we assessed in 2005-2010 and in 2009-2013 the multivariable-adjusted correlations of e' (early left ventricular relaxation) and E/e' (left ventricular filling pressure) measured by Doppler echocardiography with 43 serum metabolites, quantified by magnetic resonance spectroscopy. In 2009-2013, e' cross-sectionally increased (Bonferroni corrected p",
keywords = "ATRIAL, Biomarker, DYSFUNCTION, GLUTAMINE, HEART-FAILURE, branched-chain amino acids, diastolic left ventricular dysfunction, metabolomics, population science",
author = "Zhen-Yu Zhang and Marrachelli, \{Vannina G.\} and Wen-Yi Yang and Sander Trenson and Qi-Fang Huang and Fang-Fei Wei and Lutgarde Thijs and \{Van Keer\}, Jan and Daniel Monleon and Peter Verhamme and Jens-Uwe Voigt and Tatiana Kuznetsova and Josep Redon and Staessen, \{Jan A.\}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The European Union (HEALTH-F7-305507 HOMAGE), the European Research Council (Advanced Researcher Grant 2011-294713-EPLORE and Proof-of-Concept Grant 713601-uPROPHET), the European Research Area Net for Cardiovascular Diseases (JTC2017-046-PROACT) and the Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13) currently support the Studies Coordinating Centre in Leuven. Publisher Copyright: {\textcopyright} The European Society of Cardiology 2018.",
year = "2019",
month = jan,
doi = "10.1177/2047487318797395",
language = "English",
volume = "26",
pages = "22--32",
journal = "European Journal of Preventive Cardiology",
issn = "2047-4873",
publisher = "Oxford University Press",
number = "1",
}