Diastolic Left Ventricular Function in Relation to Circulating Metabolic Biomarkers in a General Population

Zhen-Yu Zhang; Vannina G. Marrachelli; Lutgarde Thijs; Wen-Yi Yang; Fang-Fei Wei; Daniel Monleon; Lotte Jacobs; Tim Nawrot; Peter Verhamme; Jens-Uwe Voigt; Tatiana Kuznetsova; Josep Redon; Jan A. Staessen

doi:10.1161/JAHA.115.002681

Diastolic Left Ventricular Function in Relation to Circulating Metabolic Biomarkers in a General Population

Zhen-Yu Zhang, Vannina G. Marrachelli, Lutgarde Thijs, Wen-Yi Yang, Fang-Fei Wei, Daniel Monleon, Lotte Jacobs, Tim Nawrot, Peter Verhamme, Jens-Uwe Voigt, Tatiana Kuznetsova, Josep Redon, Jan A. Staessen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background-The metabolic signature associated with subclinical diastolic left ventricular (LV) dysfunction in the population remains ill defined. Methods and Results-In 711 randomly recruited Flemish (50.8% women; mean age, 50.8 years), we assessed echocardiographic Doppler indexes of diastolic LV function in relation to 44 circulating metabolites determined by nuclear magnetic resonance spectroscopy. In multivariable-adjusted regression analysis with Bonferroni correction of significance levels applied, peak a' decreased (P

Original language	English
Article number	e002681
Journal	Journal of the American Heart Association
Volume	5
Issue number	3
DOIs	https://doi.org/10.1161/JAHA.115.002681
Publication status	Published - Mar 2016

Keywords

biomarker
diastolic left ventricular function
metabolomics
nuclear magnetic resonance spectroscopy
population science

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10.1161/JAHA.115.002681Licence: CC BY-NC-ND

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Zhang, Z.-Y., Marrachelli, V. G., Thijs, L., Yang, W.-Y., Wei, F.-F., Monleon, D., Jacobs, L., Nawrot, T., Verhamme, P., Voigt, J.-U., Kuznetsova, T., Redon, J., & Staessen, J. A. (2016). Diastolic Left Ventricular Function in Relation to Circulating Metabolic Biomarkers in a General Population. Journal of the American Heart Association, 5(3), Article e002681. https://doi.org/10.1161/JAHA.115.002681

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title = "Diastolic Left Ventricular Function in Relation to Circulating Metabolic Biomarkers in a General Population",

abstract = "Background-The metabolic signature associated with subclinical diastolic left ventricular (LV) dysfunction in the population remains ill defined. Methods and Results-In 711 randomly recruited Flemish (50.8\% women; mean age, 50.8 years), we assessed echocardiographic Doppler indexes of diastolic LV function in relation to 44 circulating metabolites determined by nuclear magnetic resonance spectroscopy. In multivariable-adjusted regression analysis with Bonferroni correction of significance levels applied, peak a' decreased (P ",

keywords = "biomarker, diastolic left ventricular function, metabolomics, nuclear magnetic resonance spectroscopy, population science",

author = "Zhen-Yu Zhang and Marrachelli, \{Vannina G.\} and Lutgarde Thijs and Wen-Yi Yang and Fang-Fei Wei and Daniel Monleon and Lotte Jacobs and Tim Nawrot and Peter Verhamme and Jens-Uwe Voigt and Tatiana Kuznetsova and Josep Redon and Staessen, \{Jan A.\}",

year = "2016",

month = mar,

doi = "10.1161/JAHA.115.002681",

language = "English",

volume = "5",

journal = "Journal of the American Heart Association",

issn = "2047-9980",

publisher = "Wiley",

number = "3",

}

Zhang, Z-Y, Marrachelli, VG, Thijs, L, Yang, W-Y, Wei, F-F, Monleon, D, Jacobs, L, Nawrot, T, Verhamme, P, Voigt, J-U, Kuznetsova, T, Redon, J & Staessen, JA 2016, 'Diastolic Left Ventricular Function in Relation to Circulating Metabolic Biomarkers in a General Population', Journal of the American Heart Association, vol. 5, no. 3, e002681. https://doi.org/10.1161/JAHA.115.002681

TY - JOUR

T1 - Diastolic Left Ventricular Function in Relation to Circulating Metabolic Biomarkers in a General Population

AU - Zhang, Zhen-Yu

AU - Marrachelli, Vannina G.

AU - Thijs, Lutgarde

AU - Yang, Wen-Yi

AU - Wei, Fang-Fei

AU - Monleon, Daniel

AU - Jacobs, Lotte

AU - Nawrot, Tim

AU - Verhamme, Peter

AU - Voigt, Jens-Uwe

AU - Kuznetsova, Tatiana

AU - Redon, Josep

AU - Staessen, Jan A.

PY - 2016/3

Y1 - 2016/3

N2 - Background-The metabolic signature associated with subclinical diastolic left ventricular (LV) dysfunction in the population remains ill defined. Methods and Results-In 711 randomly recruited Flemish (50.8% women; mean age, 50.8 years), we assessed echocardiographic Doppler indexes of diastolic LV function in relation to 44 circulating metabolites determined by nuclear magnetic resonance spectroscopy. In multivariable-adjusted regression analysis with Bonferroni correction of significance levels applied, peak a' decreased (P

AB - Background-The metabolic signature associated with subclinical diastolic left ventricular (LV) dysfunction in the population remains ill defined. Methods and Results-In 711 randomly recruited Flemish (50.8% women; mean age, 50.8 years), we assessed echocardiographic Doppler indexes of diastolic LV function in relation to 44 circulating metabolites determined by nuclear magnetic resonance spectroscopy. In multivariable-adjusted regression analysis with Bonferroni correction of significance levels applied, peak a' decreased (P

KW - biomarker

KW - diastolic left ventricular function

KW - metabolomics

KW - nuclear magnetic resonance spectroscopy

KW - population science

U2 - 10.1161/JAHA.115.002681

DO - 10.1161/JAHA.115.002681

M3 - Article

C2 - 27025885

SN - 2047-9980

VL - 5

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

IS - 3

M1 - e002681

ER -

Diastolic Left Ventricular Function in Relation to Circulating Metabolic Biomarkers in a General Population

Abstract

Keywords

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