Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study

Zhen-Yu Zhang; Vannina G. Marrachelli; Wen-Yi Yang; Sander Trenson; Qi-Fang Huang; Fang-Fei Wei; Lutgarde Thijs; Jan Van Keer; Daniel Monleon; Peter Verhamme; Jens-Uwe Voigt; Tatiana Kuznetsova; Josep Redon; Jan A. Staessen

doi:10.1177/2047487318797395

Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study

Zhen-Yu Zhang, Vannina G. Marrachelli, Wen-Yi Yang, Sander Trenson, Qi-Fang Huang, Fang-Fei Wei, Lutgarde Thijs, Jan Van Keer, Daniel Monleon, Peter Verhamme, Jens-Uwe Voigt, Tatiana Kuznetsova, Josep Redon, Jan A. Staessen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Aims We studied the association of circulating metabolic biomarkers with asymptomatic left ventricular diastolic dysfunction, a risk-carrying condition that affects 25% of the population. Methods and results In 570 randomly recruited people, we assessed in 2005-2010 and in 2009-2013 the multivariable-adjusted correlations of e' (early left ventricular relaxation) and E/e' (left ventricular filling pressure) measured by Doppler echocardiography with 43 serum metabolites, quantified by magnetic resonance spectroscopy. In 2009-2013, e' cross-sectionally increased (Bonferroni corrected p

Original language	English
Pages (from-to)	22-32
Number of pages	11
Journal	European Journal of Preventive Cardiology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1177/2047487318797395
Publication status	Published - Jan 2019

Keywords

Biomarker
branched-chain amino acids
diastolic left ventricular dysfunction
metabolomics
population science
HEART-FAILURE
DYSFUNCTION
GLUTAMINE
ATRIAL

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10.1177/2047487318797395

Cite this

Zhang, Z-Y., Marrachelli, V. G., Yang, W-Y., Trenson, S., Huang, Q-F., Wei, F-F., Thijs, L., Van Keer, J., Monleon, D., Verhamme, P., Voigt, J-U., Kuznetsova, T., Redon, J., & Staessen, J. A. (2019). Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study. European Journal of Preventive Cardiology, 26(1), 22-32. https://doi.org/10.1177/2047487318797395

@article{c73da1a22f8b4d61a3cd4ce5630709d7,

title = "Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study",

abstract = "Aims We studied the association of circulating metabolic biomarkers with asymptomatic left ventricular diastolic dysfunction, a risk-carrying condition that affects 25% of the population. Methods and results In 570 randomly recruited people, we assessed in 2005-2010 and in 2009-2013 the multivariable-adjusted correlations of e' (early left ventricular relaxation) and E/e' (left ventricular filling pressure) measured by Doppler echocardiography with 43 serum metabolites, quantified by magnetic resonance spectroscopy. In 2009-2013, e' cross-sectionally increased (Bonferroni corrected p",

keywords = "Biomarker, branched-chain amino acids, diastolic left ventricular dysfunction, metabolomics, population science, HEART-FAILURE, DYSFUNCTION, GLUTAMINE, ATRIAL",

author = "Zhen-Yu Zhang and Marrachelli, {Vannina G.} and Wen-Yi Yang and Sander Trenson and Qi-Fang Huang and Fang-Fei Wei and Lutgarde Thijs and {Van Keer}, Jan and Daniel Monleon and Peter Verhamme and Jens-Uwe Voigt and Tatiana Kuznetsova and Josep Redon and Staessen, {Jan A.}",

year = "2019",

month = jan,

doi = "10.1177/2047487318797395",

language = "English",

volume = "26",

pages = "22--32",

journal = "European Journal of Preventive Cardiology",

issn = "2047-4873",

publisher = "SAGE Publications Ltd",

number = "1",

}

Zhang, Z-Y, Marrachelli, VG, Yang, W-Y, Trenson, S, Huang, Q-F, Wei, F-F, Thijs, L, Van Keer, J, Monleon, D, Verhamme, P, Voigt, J-U, Kuznetsova, T, Redon, J & Staessen, JA 2019, 'Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study', European Journal of Preventive Cardiology, vol. 26, no. 1, pp. 22-32. https://doi.org/10.1177/2047487318797395

TY - JOUR

T1 - Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study

AU - Zhang, Zhen-Yu

AU - Marrachelli, Vannina G.

AU - Yang, Wen-Yi

AU - Trenson, Sander

AU - Huang, Qi-Fang

AU - Wei, Fang-Fei

AU - Thijs, Lutgarde

AU - Van Keer, Jan

AU - Monleon, Daniel

AU - Verhamme, Peter

AU - Voigt, Jens-Uwe

AU - Kuznetsova, Tatiana

AU - Redon, Josep

AU - Staessen, Jan A.

PY - 2019/1

Y1 - 2019/1

N2 - Aims We studied the association of circulating metabolic biomarkers with asymptomatic left ventricular diastolic dysfunction, a risk-carrying condition that affects 25% of the population. Methods and results In 570 randomly recruited people, we assessed in 2005-2010 and in 2009-2013 the multivariable-adjusted correlations of e' (early left ventricular relaxation) and E/e' (left ventricular filling pressure) measured by Doppler echocardiography with 43 serum metabolites, quantified by magnetic resonance spectroscopy. In 2009-2013, e' cross-sectionally increased (Bonferroni corrected p

AB - Aims We studied the association of circulating metabolic biomarkers with asymptomatic left ventricular diastolic dysfunction, a risk-carrying condition that affects 25% of the population. Methods and results In 570 randomly recruited people, we assessed in 2005-2010 and in 2009-2013 the multivariable-adjusted correlations of e' (early left ventricular relaxation) and E/e' (left ventricular filling pressure) measured by Doppler echocardiography with 43 serum metabolites, quantified by magnetic resonance spectroscopy. In 2009-2013, e' cross-sectionally increased (Bonferroni corrected p

KW - Biomarker

KW - branched-chain amino acids

KW - diastolic left ventricular dysfunction

KW - metabolomics

KW - population science

KW - HEART-FAILURE

KW - DYSFUNCTION

KW - GLUTAMINE

KW - ATRIAL

U2 - 10.1177/2047487318797395

DO - 10.1177/2047487318797395

M3 - Article

C2 - 30196724

VL - 26

SP - 22

EP - 32

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

SN - 2047-4873

IS - 1

ER -