Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study

Zhen-Yu Zhang, Vannina G. Marrachelli, Wen-Yi Yang, Sander Trenson, Qi-Fang Huang, Fang-Fei Wei, Lutgarde Thijs, Jan Van Keer, Daniel Monleon, Peter Verhamme, Jens-Uwe Voigt, Tatiana Kuznetsova, Josep Redon, Jan A. Staessen*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Aims We studied the association of circulating metabolic biomarkers with asymptomatic left ventricular diastolic dysfunction, a risk-carrying condition that affects 25% of the population. Methods and results In 570 randomly recruited people, we assessed in 2005-2010 and in 2009-2013 the multivariable-adjusted correlations of e' (early left ventricular relaxation) and E/e' (left ventricular filling pressure) measured by Doppler echocardiography with 43 serum metabolites, quantified by magnetic resonance spectroscopy. In 2009-2013, e' cross-sectionally increased (Bonferroni corrected p

Original languageEnglish
Pages (from-to)22-32
Number of pages11
JournalEuropean Journal of Preventive Cardiology
Issue number1
Publication statusPublished - Jan 2019


  • Biomarker
  • branched-chain amino acids
  • diastolic left ventricular dysfunction
  • metabolomics
  • population science

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