Abstract
Aims We studied the association of circulating metabolic biomarkers with asymptomatic left ventricular diastolic dysfunction, a risk-carrying condition that affects 25% of the population. Methods and results In 570 randomly recruited people, we assessed in 2005-2010 and in 2009-2013 the multivariable-adjusted correlations of e' (early left ventricular relaxation) and E/e' (left ventricular filling pressure) measured by Doppler echocardiography with 43 serum metabolites, quantified by magnetic resonance spectroscopy. In 2009-2013, e' cross-sectionally increased (Bonferroni corrected p
Original language | English |
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Pages (from-to) | 22-32 |
Number of pages | 11 |
Journal | European Journal of Preventive Cardiology |
Volume | 26 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2019 |
Keywords
- Biomarker
- branched-chain amino acids
- diastolic left ventricular dysfunction
- metabolomics
- population science
- HEART-FAILURE
- DYSFUNCTION
- GLUTAMINE
- ATRIAL