Diastolic Augmentation Index Improves Radial Augmentation Index in Assessing Arterial Stiffness

Yang Yao, Liling Hao, Lisheng Xu*, Yahui Zhang, Lin Qi, Yingxian Sun, Benqiang Yang*, Frans N. van de Vosse, Yudong Yao

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Web of Science)

Abstract

Arterial stiffness is an important risk factor for cardiovascular events. Radial augmentation index (AI(r)) can be more conveniently measured compared with carotid-femoral pulse wave velocity (cfPWV). However, the performance of AI(r) in assessing arterial stiffness is limited. This study proposes a novel index AI(rd), a combination of AI(r) and diastolic augmentation index (AI(d)) with a weight a, to achieve better performance over AI(r) in assessing arterial stiffness. 120 subjects (43 +/- 21 years old) were enrolled. The best-fit a is determined by the best correlation coefficient between AI(rd) and cfPWV. The performance of the method was tested using the 12-fold cross validation method. AI(rd) (r = 0.68, P <0.001) shows a stronger correlation with cfPWV and a narrower prediction interval than AI(r) (r = 0.61, P <0.001), AI(d) (r = -0.17, P = 0.06), the central augmentation index (AI(c)) (r = 0.61, P <0.001) or AI(c) normalized for heart rate of 75 bpm (r = 0.65, P <0.001). Compared with AI(r) (age, P <0.001; gender, P <0.001; heart rate, P <0.001; diastolic blood pressure, P <0.001; weight, P = 0.001), AI(rd) has fewer confounding factors (age, P <0.001; gender, P <0.001). In conclusion, AI(rd) derives performance improvement in assessing arterial stiffness, with a stronger correlation with cfPWV and fewer confounding factors.

Original languageEnglish
Article number5864
Number of pages7
JournalScientific Reports
Volume7
DOIs
Publication statusPublished - 19 Jul 2017

Keywords

  • PRESSURE WAVE-FORM
  • EXPERT CONSENSUS DOCUMENT
  • PULSE TRANSIT-TIME
  • CLINICAL-APPLICATIONS
  • AORTIC PRESSURE
  • BLOOD-PRESSURE
  • HYPERTENSION
  • VELOCITY
  • REFLECTIONS
  • POPULATION

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