Diagnostische Biomarker des Schädel-Hirn-Traumas

L Wanke-Jellinek; M van Griensven; P Biberthaler

doi:10.1007/s00113-013-2542-7

Diagnostische Biomarker des Schädel-Hirn-Traumas

Translated title of the contribution: Diagnostic biomarkers in traumatic brain injury

L Wanke-Jellinek^*, M van Griensven, P Biberthaler

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

BACKGROUND: Despite advances in medicine in head trauma management, traumatic brain injury (TBI) still remains a serious health concern, affecting people regardless of age. It is a leading cause of morbidity and mortality particularly in children and young adults. Therefore, studies are being carried out to try to establish reliable biomarkers to improve the accuracy of TBI diagnosis and associated secondary pathologies.

METHODS: Implementation of valid TBI biomarkers could possibly reduce the necessity to use computed cranial tomography (CCT), especially in patients suffering from mild TBI to rule out intracranial bleeding.

AIM: This review provides a critical assessment of biomarkers currently under investigation and their clinical value for the diagnosis, treatment and outcome prediction of TBI.

Translated title of the contribution	Diagnostic biomarkers in traumatic brain injury
Original language	German
Pages (from-to)	693-8
Number of pages	6
Journal	Unfallchirurg
Volume	117
Issue number	8
DOIs	https://doi.org/10.1007/s00113-013-2542-7
Publication status	Published - Aug 2014
Externally published	Yes

Keywords

Biomarkers/blood
Brain Injuries/blood
Cytokines/blood
Evidence-Based Medicine
Humans
Prognosis

Access to Document

10.1007/s00113-013-2542-7

Cite this

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title = "Diagnostische Biomarker des Sch{\"a}del-Hirn-Traumas",

abstract = "BACKGROUND: Despite advances in medicine in head trauma management, traumatic brain injury (TBI) still remains a serious health concern, affecting people regardless of age. It is a leading cause of morbidity and mortality particularly in children and young adults. Therefore, studies are being carried out to try to establish reliable biomarkers to improve the accuracy of TBI diagnosis and associated secondary pathologies.METHODS: Implementation of valid TBI biomarkers could possibly reduce the necessity to use computed cranial tomography (CCT), especially in patients suffering from mild TBI to rule out intracranial bleeding.AIM: This review provides a critical assessment of biomarkers currently under investigation and their clinical value for the diagnosis, treatment and outcome prediction of TBI.",

keywords = "Biomarkers/blood, Brain Injuries/blood, Cytokines/blood, Evidence-Based Medicine, Humans, Prognosis",

author = "L Wanke-Jellinek and {van Griensven}, M and P Biberthaler",

year = "2014",

month = aug,

doi = "10.1007/s00113-013-2542-7",

language = "German",

volume = "117",

pages = "693--8",

journal = "Unfallchirurg",

issn = "0177-5537",

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T1 - Diagnostische Biomarker des Schädel-Hirn-Traumas

AU - Wanke-Jellinek, L

AU - van Griensven, M

AU - Biberthaler, P

PY - 2014/8

Y1 - 2014/8

N2 - BACKGROUND: Despite advances in medicine in head trauma management, traumatic brain injury (TBI) still remains a serious health concern, affecting people regardless of age. It is a leading cause of morbidity and mortality particularly in children and young adults. Therefore, studies are being carried out to try to establish reliable biomarkers to improve the accuracy of TBI diagnosis and associated secondary pathologies.METHODS: Implementation of valid TBI biomarkers could possibly reduce the necessity to use computed cranial tomography (CCT), especially in patients suffering from mild TBI to rule out intracranial bleeding.AIM: This review provides a critical assessment of biomarkers currently under investigation and their clinical value for the diagnosis, treatment and outcome prediction of TBI.

AB - BACKGROUND: Despite advances in medicine in head trauma management, traumatic brain injury (TBI) still remains a serious health concern, affecting people regardless of age. It is a leading cause of morbidity and mortality particularly in children and young adults. Therefore, studies are being carried out to try to establish reliable biomarkers to improve the accuracy of TBI diagnosis and associated secondary pathologies.METHODS: Implementation of valid TBI biomarkers could possibly reduce the necessity to use computed cranial tomography (CCT), especially in patients suffering from mild TBI to rule out intracranial bleeding.AIM: This review provides a critical assessment of biomarkers currently under investigation and their clinical value for the diagnosis, treatment and outcome prediction of TBI.

KW - Biomarkers/blood

KW - Brain Injuries/blood

KW - Cytokines/blood

KW - Evidence-Based Medicine

KW - Humans

KW - Prognosis

U2 - 10.1007/s00113-013-2542-7

DO - 10.1007/s00113-013-2542-7

M3 - (Systematic) Review article

C2 - 25116011

SN - 0177-5537

VL - 117

SP - 693

EP - 698

JO - Unfallchirurg

JF - Unfallchirurg

IS - 8

ER -