Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations

Desiree Abdurrachim, Miranda Nabben, Verena Hoerr, Michael T. Kuhlmann, Philipp Bovenkamp, Jolita Ciapaite, Ilvy M. E. Geraets, Will Coumans, Joost J. F. P. Luiken, Jan F. C. Glatz, Michael Schaefers, Klaas Nicolay, Cornelius Faber, Sven Hermann, Jeanine J. Prompers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1148-1160
Number of pages13
JournalCardiovascular Research
Volume113
Issue number10
DOIs
Publication statusPublished - 1 Aug 2017

Keywords

  • Heart failure
  • Pressure overload
  • Diabetes
  • Substrate metabolism
  • In vivo imaging techniques
  • FATTY-ACID OXIDATION
  • ENERGY PHOSPHATE METABOLITES
  • ACTIVATED-RECEPTOR-ALPHA
  • PROTEIN-KINASE D1
  • DILATED CARDIOMYOPATHY
  • GLUCOSE-METABOLISM
  • DIASTOLIC DYSFUNCTION
  • INSULIN-RESISTANCE
  • HYPERTROPHY
  • PREVENTS

Cite this

Abdurrachim, D., Nabben, M., Hoerr, V., Kuhlmann, M. T., Bovenkamp, P., Ciapaite, J., Geraets, I. M. E., Coumans, W., Luiken, J. J. F. P., Glatz, J. F. C., Schaefers, M., Nicolay, K., Faber, C., Hermann, S., & Prompers, J. J. (2017). Diabetic db/db mice do not develop heart failure upon pressure overload: a longitudinal in vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations. Cardiovascular Research, 113(10), 1148-1160. https://doi.org/10.1093/cvr/cvx100