Diabetes and Atrial Fibrillation: Insight From Basic to Translational Science Into the Mechanisms and Management

Bharat K. Kantharia; Mohammadreza Tabary; Lingling Wu; Xinyu Wang; Bharat Narasimhan; Dominik Linz; Jordi Heijman; Xander H. T. Wehrens

doi:10.1111/jce.16655

Diabetes and Atrial Fibrillation: Insight From Basic to Translational Science Into the Mechanisms and Management

Bharat K. Kantharia^*, Mohammadreza Tabary, Lingling Wu, Xinyu Wang, Bharat Narasimhan, Dominik Linz, Jordi Heijman, Xander H. T. Wehrens

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

In spite of significant progress made in the management in recent decades, atrial fibrillation (AF) continues to cause increased mortality and significant morbidities, including heart failure and stroke. Diabetes mellitus (DM) is an independent risk factor for AF, and adds risks to increased mortality and hospitalizations when present along with AF. The pathophysiology of AF related to DM is complex with many inter-related factors. Atrial cardiomyopathy (atriopathy) related to structural changes from subcellular abnormalities and fibrosis, coupled with cardiac mechanical dysfunction, abnormal ion expression, dysregulation of the renin-angiotensin-aldosterone system and the autonomic nervous system function, play crucial roles in genesis and progression of AF. In this review, we discuss insights from basic to translational science into the mechanisms and management related to AF associated with DM.

Original language	English
Number of pages	12
Journal	Journal of Cardiovascular Electrophysiology
DOIs	https://doi.org/10.1111/jce.16655
Publication status	E-pub ahead of print - 1 Apr 2025

Keywords

antidiabetic drugs
atrial cardiomyopathy
atrial fibrillation
atriopathy
diabetes mellitus
fibrosis
inflammation
NF-KAPPA-B
OXIDATIVE STRESS
RISK-FACTORS
CATHETER ABLATION
SGLT2 INHIBITORS
MELLITUS
FIBROSIS
GLUCOSE
CARDIOMYOCYTES
DAPAGLIFLOZIN

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10.1111/jce.16655

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@article{d741c5f7704142d9a589b5206fb649fc,

title = "Diabetes and Atrial Fibrillation: Insight From Basic to Translational Science Into the Mechanisms and Management",

abstract = "In spite of significant progress made in the management in recent decades, atrial fibrillation (AF) continues to cause increased mortality and significant morbidities, including heart failure and stroke. Diabetes mellitus (DM) is an independent risk factor for AF, and adds risks to increased mortality and hospitalizations when present along with AF. The pathophysiology of AF related to DM is complex with many inter-related factors. Atrial cardiomyopathy (atriopathy) related to structural changes from subcellular abnormalities and fibrosis, coupled with cardiac mechanical dysfunction, abnormal ion expression, dysregulation of the renin-angiotensin-aldosterone system and the autonomic nervous system function, play crucial roles in genesis and progression of AF. In this review, we discuss insights from basic to translational science into the mechanisms and management related to AF associated with DM.",

keywords = "antidiabetic drugs, atrial cardiomyopathy, atrial fibrillation, atriopathy, diabetes mellitus, fibrosis, inflammation, NF-KAPPA-B, OXIDATIVE STRESS, RISK-FACTORS, CATHETER ABLATION, SGLT2 INHIBITORS, MELLITUS, FIBROSIS, GLUCOSE, CARDIOMYOCYTES, DAPAGLIFLOZIN",

author = "Kantharia, {Bharat K.} and Mohammadreza Tabary and Lingling Wu and Xinyu Wang and Bharat Narasimhan and Dominik Linz and Jordi Heijman and Wehrens, {Xander H. T.}",

year = "2025",

month = apr,

day = "1",

doi = "10.1111/jce.16655",

language = "English",

journal = "Journal of Cardiovascular Electrophysiology",

issn = "1045-3873",

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TY - JOUR

T1 - Diabetes and Atrial Fibrillation

T2 - Insight From Basic to Translational Science Into the Mechanisms and Management

AU - Kantharia, Bharat K.

AU - Tabary, Mohammadreza

AU - Wu, Lingling

AU - Wang, Xinyu

AU - Narasimhan, Bharat

AU - Linz, Dominik

AU - Heijman, Jordi

AU - Wehrens, Xander H. T.

PY - 2025/4/1

Y1 - 2025/4/1

N2 - In spite of significant progress made in the management in recent decades, atrial fibrillation (AF) continues to cause increased mortality and significant morbidities, including heart failure and stroke. Diabetes mellitus (DM) is an independent risk factor for AF, and adds risks to increased mortality and hospitalizations when present along with AF. The pathophysiology of AF related to DM is complex with many inter-related factors. Atrial cardiomyopathy (atriopathy) related to structural changes from subcellular abnormalities and fibrosis, coupled with cardiac mechanical dysfunction, abnormal ion expression, dysregulation of the renin-angiotensin-aldosterone system and the autonomic nervous system function, play crucial roles in genesis and progression of AF. In this review, we discuss insights from basic to translational science into the mechanisms and management related to AF associated with DM.

AB - In spite of significant progress made in the management in recent decades, atrial fibrillation (AF) continues to cause increased mortality and significant morbidities, including heart failure and stroke. Diabetes mellitus (DM) is an independent risk factor for AF, and adds risks to increased mortality and hospitalizations when present along with AF. The pathophysiology of AF related to DM is complex with many inter-related factors. Atrial cardiomyopathy (atriopathy) related to structural changes from subcellular abnormalities and fibrosis, coupled with cardiac mechanical dysfunction, abnormal ion expression, dysregulation of the renin-angiotensin-aldosterone system and the autonomic nervous system function, play crucial roles in genesis and progression of AF. In this review, we discuss insights from basic to translational science into the mechanisms and management related to AF associated with DM.

KW - antidiabetic drugs

KW - atrial cardiomyopathy

KW - atrial fibrillation

KW - atriopathy

KW - diabetes mellitus

KW - fibrosis

KW - inflammation

KW - NF-KAPPA-B

KW - OXIDATIVE STRESS

KW - RISK-FACTORS

KW - CATHETER ABLATION

KW - SGLT2 INHIBITORS

KW - MELLITUS

KW - FIBROSIS

KW - GLUCOSE

KW - CARDIOMYOCYTES

KW - DAPAGLIFLOZIN

U2 - 10.1111/jce.16655

DO - 10.1111/jce.16655

M3 - (Systematic) Review article

SN - 1045-3873

JO - Journal of Cardiovascular Electrophysiology

JF - Journal of Cardiovascular Electrophysiology

ER -

Diabetes and Atrial Fibrillation: Insight From Basic to Translational Science Into the Mechanisms and Management

Abstract

Keywords

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