Developmental neurobiology as a guide for pharmacological management of pain in neonates

Nynke J. van den Hoogen*, Anne R. de Kort, Karel M. Allegaert, Elbert A. Joosten, Sinno H. P. Simons, Dick Tibboel, Gerbrich E. van den Bosch

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Pain in newborn children should be prevented due to negative short- and long-term consequences. A good understanding of the development of the nociceptive system in newborns is necessary to enable optimal pain assessment, and most importantly to treat and prevent pain adequately in neonates. So far, preclinical juvenile animal studies have led to a tremendous amount of information regarding the development of the nociceptive system. In addition, they have made clear that the developmental stage of the nociceptive system may influence the mechanism of action of different classes of analgesics. Age specific analgesic therapy, based on post-menstrual age, should therefore be considered by incorporating information on the developmental stages of the nociceptive system in combination with knowledge from pharmacokinetic and dynamic studies in neonates.

Original languageEnglish
Article number101012
Number of pages7
JournalSeminars in Fetal & Neonatal Medicine
Volume24
Issue number4
DOIs
Publication statusPublished - Aug 2019

Keywords

  • LONG-TERM CONSEQUENCES
  • FACIAL CODING SYSTEM
  • COLD PRESSOR TASK
  • RAT SPINAL-CORD
  • INTRAVENOUS PARACETAMOL
  • POSTNATAL-DEVELOPMENT
  • MORPHINE ANALGESIA
  • NEWBORN-INFANTS
  • PROCEDURAL PAIN
  • DORSAL-HORN

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