Development of Radiotracers for Breast Cancer-The Tumor Microenvironment as an Emerging Target

Amelie Heesch, Jochen Maurer, Elmar Stickeler, Mohsen Beheshti, Felix M. Mottaghy, Agnieszka Morgenroth*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Web of Science)

Abstract

Molecular imaging plays an increasingly important role in the diagnosis and treatment of different malignancies. Radiolabeled probes enable the visualization of the primary tumor as well as the metastases and have been also employed in targeted therapy and theranostic approaches. With breast cancer being the most common malignancy in women worldwide it is of special interest to develop novel targeted treatments. However, tumor microenvironment and escape mechanisms often limit their therapeutic potential. Addressing tumor stroma associated targets provides a promising option to inhibit tumor growth and angiogenesis and to disrupt tumor tissue architecture. This review describes recent developments on radiolabeled probes used in diagnosis and treatment of breast cancer especially in triple negative type with the focus on potential targets offered by the tumor microenvironment, like tumor associated macrophages, cancer associated fibroblasts, and endothelial cells.

Original languageEnglish
Article number2334
Number of pages21
JournalCells
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 2020

Keywords

  • breast cancer
  • radiotracer
  • molecular imaging
  • targeted treatment
  • tumor microenvironment
  • RADIONUCLIDE THERAPY
  • MEMBRANE ANTIGEN
  • GROWTH-FACTOR
  • PRECLINICAL EVALUATION
  • RECEPTOR EXPRESSION
  • PET TRACER
  • ESTROGEN
  • MACROPHAGES
  • PATTERNS
  • MODELS

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