Development of hyaluronan-based membranes for the healing of intestinal surgical wounds: a preliminary study

Francesca Scognamiglio; Andrea Travan; Rossana Bussani; Massimiliano Borgogna; Ivan Donati; Joanna W. A. M. Bosmans; Nicole D. Bouvy; Eleonora Marsich

doi:10.1007/s10856-019-6262-6

Development of hyaluronan-based membranes for the healing of intestinal surgical wounds: a preliminary study

Francesca Scognamiglio^*, Andrea Travan, Rossana Bussani, Massimiliano Borgogna, Ivan Donati, Joanna W. A. M. Bosmans, Nicole D. Bouvy, Eleonora Marsich

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Web of Science)

Abstract

Implantable membranes based on alginate and hyaluronic acid (HA) were manufactured to obtain a rapidly resorbing pliable mesh for the in situ administration of HA to intestinal tissue. Morphological analyses of this interpenetrated matrix pointed out a homogeneous polymeric texture while degradation studies demonstrated that the material is able to dissolve in physiological solutions within few days. Biological studies in vitro showed that the membrane is biocompatible towards human dermal fibroblasts and that liquid extracts from the HA-containing membrane can stimulate wound healing. A preliminary in vivo biocompatibility study on rats showed that the membranes in direct contact with the intestine did not elicit any acute adverse reaction or immune response, while only a mild inflammatory reaction was noticed at the mesenteric or serosal region. Overall, these results appear to support the application of these polysaccharide-based materials for intestinal wound healing.

[GRAPHICS]

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Original language	English
Article number	60
Pages (from-to)	1-9
Number of pages	9
Journal	Journal of Materials Science-Materials in Medicine
Volume	30
Issue number	6
DOIs	https://doi.org/10.1007/s10856-019-6262-6
Publication status	Published - Jun 2019

Keywords

POLYSACCHARIDIC MEMBRANES
ACID
REINFORCEMENT
POLYMER

Access to Document

10.1007/s10856-019-6262-6

Cite this

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title = "Development of hyaluronan-based membranes for the healing of intestinal surgical wounds: a preliminary study",

abstract = "Implantable membranes based on alginate and hyaluronic acid (HA) were manufactured to obtain a rapidly resorbing pliable mesh for the in situ administration of HA to intestinal tissue. Morphological analyses of this interpenetrated matrix pointed out a homogeneous polymeric texture while degradation studies demonstrated that the material is able to dissolve in physiological solutions within few days. Biological studies in vitro showed that the membrane is biocompatible towards human dermal fibroblasts and that liquid extracts from the HA-containing membrane can stimulate wound healing. A preliminary in vivo biocompatibility study on rats showed that the membranes in direct contact with the intestine did not elicit any acute adverse reaction or immune response, while only a mild inflammatory reaction was noticed at the mesenteric or serosal region. Overall, these results appear to support the application of these polysaccharide-based materials for intestinal wound healing.[GRAPHICS].",

keywords = "POLYSACCHARIDIC MEMBRANES, ACID, REINFORCEMENT, POLYMER",

author = "Francesca Scognamiglio and Andrea Travan and Rossana Bussani and Massimiliano Borgogna and Ivan Donati and Bosmans, {Joanna W. A. M.} and Bouvy, {Nicole D.} and Eleonora Marsich",

year = "2019",

month = jun,

doi = "10.1007/s10856-019-6262-6",

language = "English",

volume = "30",

pages = "1--9",

journal = "Journal of Materials Science-Materials in Medicine",

issn = "0957-4530",

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TY - JOUR

T1 - Development of hyaluronan-based membranes for the healing of intestinal surgical wounds

T2 - a preliminary study

AU - Scognamiglio, Francesca

AU - Travan, Andrea

AU - Bussani, Rossana

AU - Borgogna, Massimiliano

AU - Donati, Ivan

AU - Bosmans, Joanna W. A. M.

AU - Bouvy, Nicole D.

AU - Marsich, Eleonora

PY - 2019/6

Y1 - 2019/6

N2 - Implantable membranes based on alginate and hyaluronic acid (HA) were manufactured to obtain a rapidly resorbing pliable mesh for the in situ administration of HA to intestinal tissue. Morphological analyses of this interpenetrated matrix pointed out a homogeneous polymeric texture while degradation studies demonstrated that the material is able to dissolve in physiological solutions within few days. Biological studies in vitro showed that the membrane is biocompatible towards human dermal fibroblasts and that liquid extracts from the HA-containing membrane can stimulate wound healing. A preliminary in vivo biocompatibility study on rats showed that the membranes in direct contact with the intestine did not elicit any acute adverse reaction or immune response, while only a mild inflammatory reaction was noticed at the mesenteric or serosal region. Overall, these results appear to support the application of these polysaccharide-based materials for intestinal wound healing.[GRAPHICS].

AB - Implantable membranes based on alginate and hyaluronic acid (HA) were manufactured to obtain a rapidly resorbing pliable mesh for the in situ administration of HA to intestinal tissue. Morphological analyses of this interpenetrated matrix pointed out a homogeneous polymeric texture while degradation studies demonstrated that the material is able to dissolve in physiological solutions within few days. Biological studies in vitro showed that the membrane is biocompatible towards human dermal fibroblasts and that liquid extracts from the HA-containing membrane can stimulate wound healing. A preliminary in vivo biocompatibility study on rats showed that the membranes in direct contact with the intestine did not elicit any acute adverse reaction or immune response, while only a mild inflammatory reaction was noticed at the mesenteric or serosal region. Overall, these results appear to support the application of these polysaccharide-based materials for intestinal wound healing.[GRAPHICS].

KW - POLYSACCHARIDIC MEMBRANES

KW - ACID

KW - REINFORCEMENT

KW - POLYMER

U2 - 10.1007/s10856-019-6262-6

DO - 10.1007/s10856-019-6262-6

M3 - Article

VL - 30

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JO - Journal of Materials Science-Materials in Medicine

JF - Journal of Materials Science-Materials in Medicine

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