TY - JOUR
T1 - Development of hyaluronan-based membranes for the healing of intestinal surgical wounds
T2 - a preliminary study
AU - Scognamiglio, Francesca
AU - Travan, Andrea
AU - Bussani, Rossana
AU - Borgogna, Massimiliano
AU - Donati, Ivan
AU - Bosmans, Joanna W. A. M.
AU - Bouvy, Nicole D.
AU - Marsich, Eleonora
N1 - Funding Information:
The authors would like to acknowledge Dr. Gianluca Turco for providing assistance in SEM analyses. This study was supported by the EU-FP7 Project “AnastomoSEAL” (Contract Number 280929).
Funding Information:
Acknowledgements The authors would like to acknowledge Dr. Gianluca Turco for providing assistance in SEM analyses. This study was supported by the EU-FP7 Project “AnastomoSEAL” (Contract Number 280929).
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/6
Y1 - 2019/6
N2 - Implantable membranes based on alginate and hyaluronic acid (HA) were manufactured to obtain a rapidly resorbing pliable mesh for the in situ administration of HA to intestinal tissue. Morphological analyses of this interpenetrated matrix pointed out a homogeneous polymeric texture while degradation studies demonstrated that the material is able to dissolve in physiological solutions within few days. Biological studies in vitro showed that the membrane is biocompatible towards human dermal fibroblasts and that liquid extracts from the HA-containing membrane can stimulate wound healing. A preliminary in vivo biocompatibility study on rats showed that the membranes in direct contact with the intestine did not elicit any acute adverse reaction or immune response, while only a mild inflammatory reaction was noticed at the mesenteric or serosal region. Overall, these results appear to support the application of these polysaccharide-based materials for intestinal wound healing.[GRAPHICS].
AB - Implantable membranes based on alginate and hyaluronic acid (HA) were manufactured to obtain a rapidly resorbing pliable mesh for the in situ administration of HA to intestinal tissue. Morphological analyses of this interpenetrated matrix pointed out a homogeneous polymeric texture while degradation studies demonstrated that the material is able to dissolve in physiological solutions within few days. Biological studies in vitro showed that the membrane is biocompatible towards human dermal fibroblasts and that liquid extracts from the HA-containing membrane can stimulate wound healing. A preliminary in vivo biocompatibility study on rats showed that the membranes in direct contact with the intestine did not elicit any acute adverse reaction or immune response, while only a mild inflammatory reaction was noticed at the mesenteric or serosal region. Overall, these results appear to support the application of these polysaccharide-based materials for intestinal wound healing.[GRAPHICS].
KW - POLYSACCHARIDIC MEMBRANES
KW - ACID
KW - REINFORCEMENT
KW - POLYMER
U2 - 10.1007/s10856-019-6262-6
DO - 10.1007/s10856-019-6262-6
M3 - Article
SN - 0957-4530
VL - 30
SP - 1
EP - 9
JO - Journal of Materials Science-Materials in Medicine
JF - Journal of Materials Science-Materials in Medicine
IS - 6
M1 - 60
ER -