Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range

Feng Ning*, Lei Zhang, Jacqueline M. Dekker, Altan Onat, Coen D. A. Stehouwer, John S. Yudkin, Tiina Laatikainen, Jaakko Tuomilehto, Kalevi Pyorala, Qing Qiao

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Web of Science)

Abstract

Background: Individuals who had normoglycemia but whose 2-hour plasma glucose (2hPG) concentrations did not return to the fasting plasma glucose (FPG) levels during an oral glucose tolerance test (OGTT) have been shown to have increased cardiovascular mortality. This is further investigated regarding to the first events of coronary heart disease (CHD) and ischemic stroke (IS). Method: Data from 9 Finnish and Swedish cohorts comprising 3743 men and 3916 women aged 25 to 90 years who had FPG <6.1 mmol/l and 2hPG <7.8 mmol/l and free of CVD at enrolment were analyzed. Hazard ratios (HRs) for first CHD and IS events were estimated for the individuals with 2hPG > FPG (Group II) compared with those having 2hPG
Original languageEnglish
Pages (from-to)76
JournalCardiovascular Diabetology
Volume11
DOIs
Publication statusPublished - 25 Jun 2012

Keywords

  • Normoglycemia
  • Coronary heart disease
  • Ischemic stroke
  • Incidence

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