Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range

Feng Ning; Lei Zhang; Jacqueline M. Dekker; Altan Onat; Coen D. A. Stehouwer; John S. Yudkin; Tiina Laatikainen; Jaakko Tuomilehto; Kalevi Pyorala; Qing Qiao

doi:10.1186/1475-2840-11-76

Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range

Feng Ning^*, Lei Zhang, Jacqueline M. Dekker, Altan Onat, Coen D. A. Stehouwer, John S. Yudkin, Tiina Laatikainen, Jaakko Tuomilehto, Kalevi Pyorala, Qing Qiao

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Individuals who had normoglycemia but whose 2-hour plasma glucose (2hPG) concentrations did not return to the fasting plasma glucose (FPG) levels during an oral glucose tolerance test (OGTT) have been shown to have increased cardiovascular mortality. This is further investigated regarding to the first events of coronary heart disease (CHD) and ischemic stroke (IS). Method: Data from 9 Finnish and Swedish cohorts comprising 3743 men and 3916 women aged 25 to 90 years who had FPG <6.1 mmol/l and 2hPG <7.8 mmol/l and free of CVD at enrolment were analyzed. Hazard ratios (HRs) for first CHD and IS events were estimated for the individuals with 2hPG > FPG (Group II) compared with those having 2hPG

Original language	English
Pages (from-to)	76
Journal	Cardiovascular Diabetology
Volume	11
DOIs	https://doi.org/10.1186/1475-2840-11-76
Publication status	Published - 25 Jun 2012

Keywords

Normoglycemia
Coronary heart disease
Ischemic stroke
Incidence

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10.1186/1475-2840-11-76Licence: CC BY

Cite this

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title = "Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range",

abstract = "Background: Individuals who had normoglycemia but whose 2-hour plasma glucose (2hPG) concentrations did not return to the fasting plasma glucose (FPG) levels during an oral glucose tolerance test (OGTT) have been shown to have increased cardiovascular mortality. This is further investigated regarding to the first events of coronary heart disease (CHD) and ischemic stroke (IS). Method: Data from 9 Finnish and Swedish cohorts comprising 3743 men and 3916 women aged 25 to 90 years who had FPG <6.1 mmol/l and 2hPG <7.8 mmol/l and free of CVD at enrolment were analyzed. Hazard ratios (HRs) for first CHD and IS events were estimated for the individuals with 2hPG > FPG (Group II) compared with those having 2hPG ",

keywords = "Normoglycemia, Coronary heart disease, Ischemic stroke, Incidence",

author = "Feng Ning and Lei Zhang and Dekker, {Jacqueline M.} and Altan Onat and Stehouwer, {Coen D. A.} and Yudkin, {John S.} and Tiina Laatikainen and Jaakko Tuomilehto and Kalevi Pyorala and Qing Qiao",

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day = "25",

doi = "10.1186/1475-2840-11-76",

language = "English",

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journal = "Cardiovascular Diabetology",

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TY - JOUR

T1 - Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range

AU - Ning, Feng

AU - Zhang, Lei

AU - Dekker, Jacqueline M.

AU - Onat, Altan

AU - Stehouwer, Coen D. A.

AU - Yudkin, John S.

AU - Laatikainen, Tiina

AU - Tuomilehto, Jaakko

AU - Pyorala, Kalevi

AU - Qiao, Qing

PY - 2012/6/25

Y1 - 2012/6/25

N2 - Background: Individuals who had normoglycemia but whose 2-hour plasma glucose (2hPG) concentrations did not return to the fasting plasma glucose (FPG) levels during an oral glucose tolerance test (OGTT) have been shown to have increased cardiovascular mortality. This is further investigated regarding to the first events of coronary heart disease (CHD) and ischemic stroke (IS). Method: Data from 9 Finnish and Swedish cohorts comprising 3743 men and 3916 women aged 25 to 90 years who had FPG <6.1 mmol/l and 2hPG <7.8 mmol/l and free of CVD at enrolment were analyzed. Hazard ratios (HRs) for first CHD and IS events were estimated for the individuals with 2hPG > FPG (Group II) compared with those having 2hPG

AB - Background: Individuals who had normoglycemia but whose 2-hour plasma glucose (2hPG) concentrations did not return to the fasting plasma glucose (FPG) levels during an oral glucose tolerance test (OGTT) have been shown to have increased cardiovascular mortality. This is further investigated regarding to the first events of coronary heart disease (CHD) and ischemic stroke (IS). Method: Data from 9 Finnish and Swedish cohorts comprising 3743 men and 3916 women aged 25 to 90 years who had FPG <6.1 mmol/l and 2hPG <7.8 mmol/l and free of CVD at enrolment were analyzed. Hazard ratios (HRs) for first CHD and IS events were estimated for the individuals with 2hPG > FPG (Group II) compared with those having 2hPG

KW - Normoglycemia

KW - Coronary heart disease

KW - Ischemic stroke

KW - Incidence

U2 - 10.1186/1475-2840-11-76

DO - 10.1186/1475-2840-11-76

M3 - Article

C2 - 22731255

SN - 1475-2840

VL - 11

SP - 76

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

ER -