Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion

Gert Jan Pelgrim; Marco Das; Ulrike Haberland; Cees Slump; Astri Handayani; Sjoerd van Tuijl; Marco Stijnen; Ernst Klotz; Matthijs Oudkerk; Joachim E. Wildberger; Rozemarijn Vliegenthart

doi:10.1155/2015/412716

Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion

Gert Jan Pelgrim
, Marco Das
, Ulrike Haberland
, Cees Slump
, Astri Handayani
, Sjoerd van Tuijl
, Marco Stijnen
, Ernst Klotz
, Matthijs Oudkerk
, Joachim E. Wildberger
, Rozemarijn Vliegenthart^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0. Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9-1.0 L/min, and arterial pressure varied between 80 and 95mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR

Original language	English
Article number	412716
Journal	BioMed Research International
DOIs	https://doi.org/10.1155/2015/412716
Publication status	Published - 2015

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@article{acf806ef47e449caab4e162d8d429d02,

title = "Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion",

abstract = "Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0. Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9-1.0 L/min, and arterial pressure varied between 80 and 95mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10\% after inducing a stenosis with FFR ",

author = "Pelgrim, \{Gert Jan\} and Marco Das and Ulrike Haberland and Cees Slump and Astri Handayani and \{van Tuijl\}, Sjoerd and Marco Stijnen and Ernst Klotz and Matthijs Oudkerk and Wildberger, \{Joachim E.\} and Rozemarijn Vliegenthart",

year = "2015",

doi = "10.1155/2015/412716",

language = "English",

journal = "BioMed Research International",

issn = "2314-6133",

publisher = "John Wiley \& Sons Inc.",

}

TY - JOUR

T1 - Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion

AU - Pelgrim, Gert Jan

AU - Das, Marco

AU - Haberland, Ulrike

AU - Slump, Cees

AU - Handayani, Astri

AU - van Tuijl, Sjoerd

AU - Stijnen, Marco

AU - Klotz, Ernst

AU - Oudkerk, Matthijs

AU - Wildberger, Joachim E.

AU - Vliegenthart, Rozemarijn

PY - 2015

Y1 - 2015

N2 - Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0. Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9-1.0 L/min, and arterial pressure varied between 80 and 95mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR

AB - Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0. Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9-1.0 L/min, and arterial pressure varied between 80 and 95mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR

U2 - 10.1155/2015/412716

DO - 10.1155/2015/412716

M3 - Article

C2 - 26185756

SN - 2314-6133

JO - BioMed Research International

JF - BioMed Research International

M1 - 412716

ER -

Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion

Abstract

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