Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion

Gert Jan Pelgrim; Marco Das; Ulrike Haberland; Cees Slump; Astri Handayani; Sjoerd van Tuijl; Marco Stijnen; Ernst Klotz; Matthijs Oudkerk; Joachim E. Wildberger; Rozemarijn Vliegenthart

doi:10.1155/2015/412716

Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion

Gert Jan Pelgrim, Marco Das, Ulrike Haberland, Cees Slump, Astri Handayani, Sjoerd van Tuijl, Marco Stijnen, Ernst Klotz, Matthijs Oudkerk, Joachim E. Wildberger, Rozemarijn Vliegenthart^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0. Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9-1.0 L/min, and arterial pressure varied between 80 and 95mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR

Original language	English
Article number	412716
Journal	BioMed Research International
DOIs	https://doi.org/10.1155/2015/412716
Publication status	Published - 2015

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10.1155/2015/412716Licence: CC BY

Cite this

@article{acf806ef47e449caab4e162d8d429d02,

title = "Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion",

abstract = "Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0. Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9-1.0 L/min, and arterial pressure varied between 80 and 95mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR ",

author = "Pelgrim, {Gert Jan} and Marco Das and Ulrike Haberland and Cees Slump and Astri Handayani and {van Tuijl}, Sjoerd and Marco Stijnen and Ernst Klotz and Matthijs Oudkerk and Wildberger, {Joachim E.} and Rozemarijn Vliegenthart",

year = "2015",

doi = "10.1155/2015/412716",

language = "English",

journal = "BioMed Research International",

issn = "2314-6133",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion

AU - Pelgrim, Gert Jan

AU - Das, Marco

AU - Haberland, Ulrike

AU - Slump, Cees

AU - Handayani, Astri

AU - van Tuijl, Sjoerd

AU - Stijnen, Marco

AU - Klotz, Ernst

AU - Oudkerk, Matthijs

AU - Wildberger, Joachim E.

AU - Vliegenthart, Rozemarijn

PY - 2015

Y1 - 2015

N2 - Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0. Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9-1.0 L/min, and arterial pressure varied between 80 and 95mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR

AB - Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0. Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9-1.0 L/min, and arterial pressure varied between 80 and 95mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR

U2 - 10.1155/2015/412716

DO - 10.1155/2015/412716

M3 - Article

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SN - 2314-6133

JO - BioMed Research International

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