TY - JOUR
T1 - Development of a scoring method to visually score cortical interruptions on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis and healthy controls
AU - Scharmga, Andrea
AU - Peters, Michiel
AU - van den Bergh, Joop P.
AU - Geusens, Piet
AU - Loeffen, Daan
AU - van Rietbergen, Bert
AU - Schoonbrood, Thea
AU - Vosse, Debby
AU - Weijers, Rene
AU - van Tubergen, Astrid
PY - 2018/7/9
Y1 - 2018/7/9
N2 - ObjectivesTo develop a scoring method to visually score cortical interruptions in finger joints on High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT), determine its intra-and inter-reader reliability and test its feasibility.MethodsThe scoring method was developed by integrating results from in-depth discussions with experts, consensus meetings, multiple reading experiments and the literature. Cortical interruptions were scored by two independent readers in an imaging dataset with finger joints from patients with rheumatoid arthritis (RA) and healthy controls and assessed for adjacent trabecular distortion. Reliability for the total number of cortical interruptions per joint and per quadrant was calculated using intraclass correlation coefficient (ICC). Feasibility was tested by recording the time to analyze one joint.ResultsIn 98 joints we identified 252 cortical interruptions, 17% had trabecular distortion. Mean diameter of the interruptions was significantly larger in patients with RA compared with healthy controls (0.88 vs 0.47 mm, p = 0.03). Intra-reader reliability was ICC 0.88 (95% CI 0.83;0.92) per joint and ICC 0.69 (95% CI 0.65;0.73) per quadrant. Inter-reader reliability was ICC 0.48 (95% CI 0.20;0.67) per joint and ICC 0.56 (95% CI 0.49;0.62) per quadrant. The time to score one joint was mean 9.2 (SD 4.9) min.ConclusionsThis scoring method allows detection of small cortical interruptions on HR-pQCT imaging of finger joints, which is promising for use in clinical studies.
AB - ObjectivesTo develop a scoring method to visually score cortical interruptions in finger joints on High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT), determine its intra-and inter-reader reliability and test its feasibility.MethodsThe scoring method was developed by integrating results from in-depth discussions with experts, consensus meetings, multiple reading experiments and the literature. Cortical interruptions were scored by two independent readers in an imaging dataset with finger joints from patients with rheumatoid arthritis (RA) and healthy controls and assessed for adjacent trabecular distortion. Reliability for the total number of cortical interruptions per joint and per quadrant was calculated using intraclass correlation coefficient (ICC). Feasibility was tested by recording the time to analyze one joint.ResultsIn 98 joints we identified 252 cortical interruptions, 17% had trabecular distortion. Mean diameter of the interruptions was significantly larger in patients with RA compared with healthy controls (0.88 vs 0.47 mm, p = 0.03). Intra-reader reliability was ICC 0.88 (95% CI 0.83;0.92) per joint and ICC 0.69 (95% CI 0.65;0.73) per quadrant. Inter-reader reliability was ICC 0.48 (95% CI 0.20;0.67) per joint and ICC 0.56 (95% CI 0.49;0.62) per quadrant. The time to score one joint was mean 9.2 (SD 4.9) min.ConclusionsThis scoring method allows detection of small cortical interruptions on HR-pQCT imaging of finger joints, which is promising for use in clinical studies.
KW - INFLAMMATORY ARTHRITIS
KW - BONE EROSION
KW - JOINTS
KW - Finger Joint/diagnostic imaging
KW - Reproducibility of Results
KW - Tomography, X-Ray Computed/methods
KW - Humans
KW - Middle Aged
KW - Cortical Bone/diagnostic imaging
KW - Adult
KW - Female
KW - Arthritis, Rheumatoid/diagnostic imaging
U2 - 10.1371/journal.pone.0200331
DO - 10.1371/journal.pone.0200331
M3 - Article
SN - 1932-6203
VL - 13
JO - PLOS ONE
JF - PLOS ONE
IS - 7
M1 - 0200331
ER -