TY - JOUR
T1 - Development of a National Indication Protocol for Proton Therapy in Patients With Seminoma Testis to Reduce the Risk on Subsequent Primary Cancers
AU - Kuijsters, Nienke
AU - Sinnige, Peter
AU - Bakker, Pauline A.
AU - Uwini, Shafak Al
AU - Brouwer, Charlotte L.
AU - Budiharto, Tom
AU - Coppes, Rob P.
AU - Dirkx, Maarten
AU - Franckena, Martine
AU - Habraken, Steven
AU - de Jong, Marianne A.A.
AU - Klaver, Yvonne L.B.
AU - Langendijk, Johannes A.
AU - Oele, Ada
AU - Schimmel, Erik
AU - Schuit, Ewoud
AU - Smeenk, Robert Jan
AU - Unipan, Mirko
AU - Vanneste, Ben
AU - Heemsbergen, Wilma D.
AU - Boersma, Liesbeth J.
N1 - Publisher Copyright:
© 2026 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license. http://creativecommons.org/licenses/by/4.0/
PY - 2026/1/1
Y1 - 2026/1/1
N2 - PurposeTo develop a National Indication Protocol for Proton therapy (PT) (NIPP) for selecting seminoma testis patients (STPs) for PT in the Netherlands, aiming at reducing the risk of subsequent primary cancers (SPCs).Methods and MaterialsA multidisciplinary workgroup developed criteria for an NIPP based on a systematic literature search. To estimate its potential, PT-photon plan comparisons were constructed for 13 historical patients, after which NIPP version 1 was finalized. First clinical results of NIPP-v1 were evaluated.ResultsFrom cohort studies, it was established that the kidney, pancreas, stomach, and bladder were the main organs at risk contributing to excess SPC risks in STPs treated with radiation therapy. Estimated excess relative risks per 1 Gy increase in mean dose were as follows: kidney, 0.13; pancreas, 0.12; stomach, 0.47; and bladder, 0.50. Combined with absolute lifetime risks from the Dutch male population (age, 30-79 years), the corresponding lifetime absolute excess risks (AERs) per 1 Gy increase were +0.20%, +0.16%, +0.28%, and +0.65%, respectively. A first exploratory analysis in 13 replanned historical patients showed potential for an NIPP, as the required AER reduction of =2% for a grade 4 adverse event was achievable in 11 cases (85%). In a provisional NIPP version 1, criteria were as follows: age =50 years; paraortic and/or para-iliac RT; and no life-threatening comorbidity. In NIPP version 2 (approved and implemented), an estimated lifetime AER reduction of =2% by PT was required as well. From the first 76 PT patients based on NIPP-v1, 71% would qualify for NIPP-v2 as well. In 39 available PT-photon comparisons, we found an average 3.0% (median, 2.9%; IQR, 2.1%) AER reduction by PT.ConclusionsWe defined an NIPP for the selection of STPs for PT in the Netherlands, aimed to reduce the risk of SPC. According to this NIPP, about 75% of these patients qualify for PT. Further studies are required to allow inclusion of nononcological late effects as selection criteria in the NIPP.
AB - PurposeTo develop a National Indication Protocol for Proton therapy (PT) (NIPP) for selecting seminoma testis patients (STPs) for PT in the Netherlands, aiming at reducing the risk of subsequent primary cancers (SPCs).Methods and MaterialsA multidisciplinary workgroup developed criteria for an NIPP based on a systematic literature search. To estimate its potential, PT-photon plan comparisons were constructed for 13 historical patients, after which NIPP version 1 was finalized. First clinical results of NIPP-v1 were evaluated.ResultsFrom cohort studies, it was established that the kidney, pancreas, stomach, and bladder were the main organs at risk contributing to excess SPC risks in STPs treated with radiation therapy. Estimated excess relative risks per 1 Gy increase in mean dose were as follows: kidney, 0.13; pancreas, 0.12; stomach, 0.47; and bladder, 0.50. Combined with absolute lifetime risks from the Dutch male population (age, 30-79 years), the corresponding lifetime absolute excess risks (AERs) per 1 Gy increase were +0.20%, +0.16%, +0.28%, and +0.65%, respectively. A first exploratory analysis in 13 replanned historical patients showed potential for an NIPP, as the required AER reduction of =2% for a grade 4 adverse event was achievable in 11 cases (85%). In a provisional NIPP version 1, criteria were as follows: age =50 years; paraortic and/or para-iliac RT; and no life-threatening comorbidity. In NIPP version 2 (approved and implemented), an estimated lifetime AER reduction of =2% by PT was required as well. From the first 76 PT patients based on NIPP-v1, 71% would qualify for NIPP-v2 as well. In 39 available PT-photon comparisons, we found an average 3.0% (median, 2.9%; IQR, 2.1%) AER reduction by PT.ConclusionsWe defined an NIPP for the selection of STPs for PT in the Netherlands, aimed to reduce the risk of SPC. According to this NIPP, about 75% of these patients qualify for PT. Further studies are required to allow inclusion of nononcological late effects as selection criteria in the NIPP.
U2 - 10.1016/j.ijrobp.2026.02.207
DO - 10.1016/j.ijrobp.2026.02.207
M3 - Article
SN - 0360-3016
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
ER -