Development and regulatory application of microRNA biomarkers

Julian Krauskopf; Marcha Verheijen; Jos C. Kleinjans; Theo M. de Kok; Florian Caiment

doi:10.2217/bmm.15.50

Development and regulatory application of microRNA biomarkers

Julian Krauskopf, Marcha Verheijen, Jos C. Kleinjans, Theo M. de Kok, Florian Caiment^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

MicroRNAs, a class of regulatory small non-coding RNAs, are emerging as promising biomarkers for different health outcomes. Due to their tissue specificity, stability in extracellular space and high conservation between preclinical test species, applications of novel miRNA-based biomarkers for drug safety testing regarding hepatotoxicity and cardiotoxicity are investigated. Furthermore, miRNA expression is altered by environmental exposure such as cigarette smoke or polychlorinated biphenyls. As a consequence, miRNAs potentially influence tumor suppressor genes and oncogenes and may influence carcinogenesis. This has raised the interest in the use of miRNA profiles for health risk assessment. This review summarizes the recent developments in miRNA research with focus on biomarkers for drug safety testing and biomarkers for health outcomes related to environmental exposures.

Original language	English
Pages (from-to)	1137-1151
Journal	Biomarkers in Medicine
Volume	9
Issue number	11
DOIs	https://doi.org/10.2217/bmm.15.50
Publication status	Published - 2015

Keywords

biomarker
cardiotoxicity
circulating miRNAs
drug safety testing
environmental exposure
hepatotoxicity
microRNA

Access to Document

10.2217/bmm.15.50

Cite this

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abstract = "MicroRNAs, a class of regulatory small non-coding RNAs, are emerging as promising biomarkers for different health outcomes. Due to their tissue specificity, stability in extracellular space and high conservation between preclinical test species, applications of novel miRNA-based biomarkers for drug safety testing regarding hepatotoxicity and cardiotoxicity are investigated. Furthermore, miRNA expression is altered by environmental exposure such as cigarette smoke or polychlorinated biphenyls. As a consequence, miRNAs potentially influence tumor suppressor genes and oncogenes and may influence carcinogenesis. This has raised the interest in the use of miRNA profiles for health risk assessment. This review summarizes the recent developments in miRNA research with focus on biomarkers for drug safety testing and biomarkers for health outcomes related to environmental exposures.",

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author = "Julian Krauskopf and Marcha Verheijen and Kleinjans, {Jos C.} and {de Kok}, {Theo M.} and Florian Caiment",

year = "2015",

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AU - Kleinjans, Jos C.

AU - de Kok, Theo M.

AU - Caiment, Florian

PY - 2015

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AB - MicroRNAs, a class of regulatory small non-coding RNAs, are emerging as promising biomarkers for different health outcomes. Due to their tissue specificity, stability in extracellular space and high conservation between preclinical test species, applications of novel miRNA-based biomarkers for drug safety testing regarding hepatotoxicity and cardiotoxicity are investigated. Furthermore, miRNA expression is altered by environmental exposure such as cigarette smoke or polychlorinated biphenyls. As a consequence, miRNAs potentially influence tumor suppressor genes and oncogenes and may influence carcinogenesis. This has raised the interest in the use of miRNA profiles for health risk assessment. This review summarizes the recent developments in miRNA research with focus on biomarkers for drug safety testing and biomarkers for health outcomes related to environmental exposures.

KW - biomarker

KW - cardiotoxicity

KW - circulating miRNAs

KW - drug safety testing

KW - environmental exposure

KW - hepatotoxicity

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