@article{316b415582234587b891eae5b000fe19,
title = "Development and external validation of predictive models for prevalent and recurrent atrial fibrillation: a protocol for the analysis of the CATCH ME combined dataset",
abstract = "Background: Atrial fibrillation (AF) is caused by different mechanisms but current treatment strategies do not target these mechanisms. Stratified therapy based on mechanistic drivers and biomarkers of AF have the potential to improve AF prevention and management outcomes. We will integrate mechanistic insights with known pathophysiological drivers of AF in models predicting recurrent AF and prevalent AF to test hypotheses related to AF mechanisms and response to rhythm control therapy.Methods: We will harmonise and combine baseline and outcome data from 12 studies collected by six centres from the United Kingdom, Germany, France, Spain, and the Netherlands which assess prevalent AF or recurrent AF. A Delphi process and statistical selection will be used to identify candidate clinical predictors. Prediction models will be developed in patients with AF for AF recurrence and AF-related outcomes, and in patients with or without AF at baseline for prevalent AF. Models will be used to test mechanistic hypotheses and investigate the predictive value of plasma biomarkers.Discussion: This retrospective, harmonised, individual patient data analysis will use information from 12 datasets collected in five European countries. It is envisioned that the outcome of this analysis would provide a greater understanding of the factors associated with recurrent and prevalent AF, potentially allowing development of stratified approaches to prevention and therapy management.",
keywords = "Atrial fibrillation, Predictive model, Combined database, Stratified therapy, CATHETER ABLATION, RISK-FACTORS, FOLLOW-UP, LIFETIME RISK, MANAGEMENT, TERM, EVENTS, STROKE, NUMBER, CARDIOVERSION",
author = "Winnie Chua and Easter, {Christina L.} and Eduard Guasch and Alice Sitch and Barbara Casadei and Crijns, {Harry J. G. M.} and Doreen Haase and Stephane Hatem and Stefan Kaab and Lluis Mont and Ulrich Schotten and Sinner, {Moritz F.} and Karla Hemming and Deeks, {Jonathan J.} and Paulus Kirchhof and Larissa Fabritz",
note = "Funding Information: This work was primarily supported by European Union (grant agreement No 633196 [CATCH ME] to PK, LF, EG, LM, US, HJGMC, SK, MFS, BC, SH, DH). Further support came from British Heart Foundation (FS/13/43/30324 to PK and LF; German Centre for Cardiovascular Research to PK, US, SK, MFS; the Netherlands Heart Foundation (CVON2014–09, RACE V: Reappraisal of Atrial Fibrillation: Interaction between hyperCoagulability, Electrical remodeling, and Vascular Destabilisation in the Progression of AF) to US; AGAUR (Ag{\`e}ncia de Gesti{\'o} d{\textquoteright}Ajuts Universitaris i de Recerca, 2017SGR1548) to EG and LM, Instituto de Salud Carlos III (PI16/00703 to EG; PI16/00435 to LM). The funding bodies did not play any roles in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. Funding Information: This paper presents independent research supported by the NIHR Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. Funding Information: BC, HJGMC, WC, CE, DH, KH, SH, EG, LM, SK, AS, MFS have nothing to disclose. JJD reports being an NIHR Senior Investigator Emeritus and is supported by the NIHR Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham. US is co-founder and shareholder of YourRhythmics BV, a spin-off company of the University Maastricht and received consultancy fees or honoraria from Roche Diagnostics (Switzerland) and Bayer Healthcare (Germany). PK has received support for research from the European Union, British Heart Foundation, Leducq Foundation, Medical Research Council (UK), and German Centre for Heart Research, from several drug and device companies active in atrial fibrillation, honoraria from several such companies; and is listed as inventor on two patents held by University of Birmingham (Atrial Fibrillation Therapy WO 2015140571, Markers for Atrial Fibrillation WO 2016012783). LF has received institutional research grants and nonfinancial support from European Union, British Heart Foundation, Medical Research Council (UK), and DFG and Gilead; and is listed as inventor on two patents held by University of Birmingham (Atrial Fibrillation Therapy WO 2015140571, Markers for Atrial Fibrillation WO 2016012783). Funding Information: This analysis protocol is approved by the University of Birmingham, UK (ERN_15–0062), and complies with ethical requirements by the European Commission for projects funded by Horizon 2020. All institutional ethical and legal regulations and requirements applicable to individual studies were adhered to during the process of data compilation and biomarker quantification. The ethics committee waived the need for consent. Publisher Copyright: {\textcopyright} 2019 The Author(s).",
year = "2019",
month = may,
day = "21",
doi = "10.1186/s12872-019-1105-4",
language = "English",
volume = "19",
journal = "BMC Cardiovascular disorders",
issn = "1471-2261",
publisher = "BioMed Central Ltd",
number = "1",
}