Development and evaluation of an online three-level proton vs photon decision support prototype for head and neck cancer - Comparison of dose, toxicity and cost-effectiveness

Qing Cheng, Erik Roelofs, Bram L. T. Ramaekers, Danielle Eekers, Johan van Soest, Tim Lustberg, Tim Hendriks, Frank Hoebers, Hans Paul van der Laan, Erik W. Korevaar, Andre Dekker, Johannes A. Langendijk, Philippe Lambin*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


To quantitatively assess the effectiveness of proton therapy for individual patients, we developed a prototype for an online platform for proton decision support (PRODECIS) comparing photon and proton treatments on dose metric, toxicity and cost-effectiveness levels. An evaluation was performed with 23 head and neck cancer datasets.
Original languageEnglish
Pages (from-to)281-285
JournalRadiotherapy and Oncology
Issue number2
Publication statusPublished - Feb 2016


  • Proton therapy
  • Decision support system
  • Quantitative comparison
  • Mean dose extraction
  • Toxicity prediction
  • Cost-effectiveness estimation

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