Development and application of toxicogenomic-based biomarkers of immunotoxic and genotoxic exposure in European neonates

K. Hochstenbach

    Research output: ThesisDoctoral ThesisInternal

    Abstract


    Exposure in the womb to toxic substances originating from the mother’s nutrition and environment can lead to changes in the gene expression in the unborn child with possible damaging effects for the child. The research described in this dissertation identified such genes. The found genes provide indications of the way exposure to damaging substances can lead to an increased risk of cancer and a less functioning immune system. Moreover, it became clear that boys and girls react differently to toxic substances, which can be associated with gender-specific risks of cancer and immune-related disorders in youth.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • Maastricht University
    Supervisors/Advisors
    • van Loveren, Henk, Supervisor
    • van Delft, Joseph, Advisor
    Award date18 Oct 2012
    Publication statusPublished - 1 Jan 2012

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