@article{3689bb1151a44759b8fe2c39b75a98cf,
title = "Developing zebrafish experimental animal models relevant to schizophrenia",
abstract = "Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1% of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and pro/antipsychotic drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.",
keywords = "Zebrafish, Rodent models, Schizophrenia, Positive symptoms, Negative symptoms, Translational research, MUTANT MOUSE MODELS, ADULT ZEBRAFISH, SOCIAL-INTERACTION, PREPULSE INHIBITION, PLACE PREFERENCE, GENE-EXPRESSION, RODENT MODELS, DANIO-RERIO, DEFICITS, MK-801",
author = "Demin, {Konstantin A.} and Meshalkina, {Darya A.} and Volgin, {Andrey D.} and Yakovlev, {Oleg V.} and {de Abreu}, {Murilo S.} and Alekseeva, {Polina A.} and Friend, {Ashton J.} and Lakstygal, {Anton M.} and Konstantin Zabegalov and Amstislayskaya, {Tamara G.} and Tatyana Strekalova and Wandong Bao and Kalueff, {Allan V.}",
note = "Funding Information: The research was supported by the Russian Science Foundation grant 19-15-00053 to AVK. KAD is supported by the President of Russia PhD Fellowship and the Rector's Special Productivity Fellowship for SPBSU PhD Students. The funders had no role in the study design, data collection and interpretation, writing the report and the decision to submit this manuscript for publication. AVK is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) that has coordinated this multi-laboratory 2018-2019 collaborative project. The authors declare no conflict of interest. Funding Information: The research was supported by the Russian Science Foundation grant 19-15-00053 to AVK. KAD is supported by the President of Russia PhD Fellowship and the Rector{\textquoteright}s Special Productivity Fellowship for SPBSU PhD Students. The funders had no role in the study design, data collection and interpretation, writing the report and the decision to submit this manuscript for publication. AVK is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) that has coordinated this multi-laboratory 2018-2019 collaborative project. The authors declare no conflict of interest. Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = oct,
doi = "10.1016/j.neubiorev.2019.07.017",
language = "English",
volume = "105",
pages = "126--133",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Elsevier Science",
}