Detrusor underactivity: Pathophysiological considerations, models and proposals for future research. ICI-RS 2013

Gommert A. van Koeveringe*, Kevin L. J. Rademakers, Lori A. Birder, Cees Korstanje, Firouz Daneshgari, Michael R. Ruggieri, Yasuhiko Igawa, Christopher Fry, Adrian Wagg

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Web of Science)

Abstract

Aims Detrusor underactivity, resulting in either prolonged or inefficient voiding, is a common clinical problem for which treatment options are currently limited. The aim of this report is to summarize current understanding of the clinical observation and its underlying pathophysiological entities. Methods This report results from presentations and subsequent discussion at the International Consultation on Incontinence Research Society (ICI-RS) in Bristol, 2013. Results and Conclusions The recommendations made by the ICI-RS panel include: Development of study tools based on a system's pathophysiological approach, correlation of in vitro and in vivo data in experimental animals and humans, and development of more comprehensive translational animal models. In addition, there is a need for longitudinal patient data to define risk groups and for the development of screening tools. In the near-future these recommendations should lead to a better understanding of detrusor underactivity and its pathophysiological background. Neurourol. Urodynam. 33:591-596, 2014.
Original languageEnglish
Pages (from-to)591-596
JournalNeurourology and Urodynamics
Volume33
Issue number5
DOIs
Publication statusPublished - Jun 2014

Keywords

  • ageing
  • detrusor underactivity
  • experimental animal models
  • lower urinary tract symptoms
  • underactive bladder
  • urinary tract physiology
  • voiding dysfunction

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