TY - JOUR
T1 - Detrusor underactivity: Pathophysiological considerations, models and proposals for future research. ICI-RS 2013
AU - van Koeveringe, Gommert A.
AU - Rademakers, Kevin L. J.
AU - Birder, Lori A.
AU - Korstanje, Cees
AU - Daneshgari, Firouz
AU - Ruggieri, Michael R.
AU - Igawa, Yasuhiko
AU - Fry, Christopher
AU - Wagg, Adrian
PY - 2014/6
Y1 - 2014/6
N2 - Aims Detrusor underactivity, resulting in either prolonged or inefficient voiding, is a common clinical problem for which treatment options are currently limited. The aim of this report is to summarize current understanding of the clinical observation and its underlying pathophysiological entities. Methods This report results from presentations and subsequent discussion at the International Consultation on Incontinence Research Society (ICI-RS) in Bristol, 2013. Results and Conclusions The recommendations made by the ICI-RS panel include: Development of study tools based on a system's pathophysiological approach, correlation of in vitro and in vivo data in experimental animals and humans, and development of more comprehensive translational animal models. In addition, there is a need for longitudinal patient data to define risk groups and for the development of screening tools. In the near-future these recommendations should lead to a better understanding of detrusor underactivity and its pathophysiological background. Neurourol. Urodynam. 33:591-596, 2014.
AB - Aims Detrusor underactivity, resulting in either prolonged or inefficient voiding, is a common clinical problem for which treatment options are currently limited. The aim of this report is to summarize current understanding of the clinical observation and its underlying pathophysiological entities. Methods This report results from presentations and subsequent discussion at the International Consultation on Incontinence Research Society (ICI-RS) in Bristol, 2013. Results and Conclusions The recommendations made by the ICI-RS panel include: Development of study tools based on a system's pathophysiological approach, correlation of in vitro and in vivo data in experimental animals and humans, and development of more comprehensive translational animal models. In addition, there is a need for longitudinal patient data to define risk groups and for the development of screening tools. In the near-future these recommendations should lead to a better understanding of detrusor underactivity and its pathophysiological background. Neurourol. Urodynam. 33:591-596, 2014.
KW - ageing
KW - detrusor underactivity
KW - experimental animal models
KW - lower urinary tract symptoms
KW - underactive bladder
KW - urinary tract physiology
KW - voiding dysfunction
U2 - 10.1002/nau.22590
DO - 10.1002/nau.22590
M3 - Article
VL - 33
SP - 591
EP - 596
JO - Neurourology and Urodynamics
JF - Neurourology and Urodynamics
SN - 0733-2467
IS - 5
ER -