TY - JOUR
T1 - Determinants of quality of life in young onset dementia - results from a European multicenter assessment
AU - Millenaar, Joany
AU - Hvidsten, Lara
AU - de Vugt, Marjolein E.
AU - Engedal, Knut
AU - Selbaek, Geir
AU - Wyller, Torgeir Bruun
AU - Johannessen, Aud
AU - Haugen, Per Kristian
AU - Bakker, Christian
AU - van Vliet, Deliane
AU - Koopmans, Raymond T. C. M.
AU - Verhey, Frans R. J.
AU - Kersten, Hege
PY - 2017
Y1 - 2017
N2 - Background: Promoting adaptation, improving well-being and maintaining an optimal quality of life (QOL) is an important aspect in dementia care. The purpose of this study was to identify determinants of QOL in young onset dementia, and to assess differences in QoL domains between people with Alzheimer's disease (AD) and frontotemporal dementia (FTD).Methods: In total 135 persons with AD and 58 persons with FTD were included from two prospective cohort studies. QOL was assessed with the proxy reported quality of life in Alzheimer's disease questionnaire (QoL-AD). Possible determinants were explored using multiple linear regression and included sociodemographic variables, diagnosis, dementia severity, disease awareness, neuropsychiatric symptoms, met and unmet needs and hours of personal and instrumental care. Differences between QOL domains in people with AD and FTD were calculated using Mann-Whitney U tests.Results: Lower QOL was associated with more depressive symptoms, lower disease awareness, and a higher amount of needs, both met and unmet. People with AD scored lower on the memory and higher on the friends' subscale. No differences were found for the other items.Conclusion: This study demonstrates a unique set of determinants of QOL in AD and FTD. Interventions directed towards these specific factors may improve QOL.
AB - Background: Promoting adaptation, improving well-being and maintaining an optimal quality of life (QOL) is an important aspect in dementia care. The purpose of this study was to identify determinants of QOL in young onset dementia, and to assess differences in QoL domains between people with Alzheimer's disease (AD) and frontotemporal dementia (FTD).Methods: In total 135 persons with AD and 58 persons with FTD were included from two prospective cohort studies. QOL was assessed with the proxy reported quality of life in Alzheimer's disease questionnaire (QoL-AD). Possible determinants were explored using multiple linear regression and included sociodemographic variables, diagnosis, dementia severity, disease awareness, neuropsychiatric symptoms, met and unmet needs and hours of personal and instrumental care. Differences between QOL domains in people with AD and FTD were calculated using Mann-Whitney U tests.Results: Lower QOL was associated with more depressive symptoms, lower disease awareness, and a higher amount of needs, both met and unmet. People with AD scored lower on the memory and higher on the friends' subscale. No differences were found for the other items.Conclusion: This study demonstrates a unique set of determinants of QOL in AD and FTD. Interventions directed towards these specific factors may improve QOL.
KW - Young onset dementia
KW - Alzheimer's disease
KW - frontotemporal dementia
KW - quality of life
KW - ALZHEIMERS-DISEASE
KW - FRONTOTEMPORAL DEMENTIA
KW - COGNITIVE IMPAIRMENT
KW - INFORMAL CAREGIVERS
KW - QOL-AD
KW - SCALE
KW - DEPRESSION
KW - RATINGS
KW - PEOPLE
KW - HEALTH
U2 - 10.1080/13607863.2016.1232369
DO - 10.1080/13607863.2016.1232369
M3 - Article
C2 - 27676211
SN - 1360-7863
VL - 21
SP - 24
EP - 30
JO - Aging & Mental Health
JF - Aging & Mental Health
IS - 1
ER -